Vitamin E: Anti-Prolactin, Anti-Estrogen, Progesterone-Sparing

"Vitamin E, like progesterone and aspirin, acts within the cellular regulatory systems, to prevent inflammation and inappropriate excitation. Since uncontrolled excitation causes destructive oxidations, these substances prevent those forms of oxidation."  - Ray Peat.

Vitamin E has long been known as a 'pro-fertility' nutrient, that is able to prevent the toxic effects of excess estrogen within and outside of pregnancy, circulatory disorders, blood clotting, lack of oxygen availability to the tissues, and more.

Researchers have called it 'progesterone-sparing' because its antiestrogenic effects seem to be very similar to the beneficial effects of progesterone.

Comparatively, PUFA themselves have many of the similar effects of estrogen. Such as decreasing oxygen supply to the tissues, suppressing thyroid, inducing cell damage, inflammation, and fibrosis.

So it really could be due to Vitamin E's protective effects against the polyunsaturated fats, that cause a beneficial hormonal cascade such as anti-estrogen, anti-prolactin, and progesterone sparing.

Vitamin E strongly protects against the toxic effects of PUFA, and some research actually suggests that it can help convert PUFA into saturated fatty acids in the colon. This could be a very important factor in the 'detox' process of PUFA. (P.E. Hughes and S.B. Tove, 1982.).

This study also shows after vitamin E supplementation prolactin levels were greatly decreased: 

Vitamin E: Anti-Prolactin, Anti-Estrogen, Progesterone-Sparing