Vitamin K2 Mk4 & Mk7
in their fully bioactive, trans-isomer form . Naturally derived.
Approximately 4 months supply.
Servings per container: 143
Serving size (10 drops):
Mk4 10,000 mcg
Mk7 200 mcg
Other ingredients: MCT oil.
Limited Time: $1 of every product sold will be donated to the independent PhD research of Keith Littlewood (https://keith-littlewood.squarespace.com/) regarding thyroid physiology and disease, specifically the endocrine disrupting environmental pollutants and their effect on thyroid health.
Vitamin K2 is the ultimate calcium regulator.
Calcium regulation is the hallmark of dental, bone, artery, and cell health.
Because calcium is, of course, an incredibly important mineral in our body and thus to have in our diet as well. BUT, it must be in the right place.
Blood calcium is the main regulator of Parathyroid Hormone (PTH) secretion, which can be thrown off by consuming more phosphorous than calcium (See blog post: 'Meat in Context'). Otherwise, the vast majority of calcium we get should be in the bones. High phosphorous intake, without adequate calcium intake will result in the raise in PTH, causing calcium to be pulled out of the bones, and into the blood. When this becomes chronic, it can result in osteoporosis and other osteo- conditions.
It is the role of both magnesium, and Vitamin K2, to direct calcium into where it belongs.
When calcium is deposited into the soft tissues, the buildup results in soft tissue calcification which can lead to stiff and aching muscles. When calcium is deposited in the blood vessels and arteries, it leads to arterial plaque which can cause serious cardiovascular issues, and high blood pressure,
During stress, calcium floods into the cell and causes cellular inflammation, excitation, and can cause cell death.
Vitamin K2 plays a crucial role in pulling calcium out of the soft tissues, and the arteries, and directing it back into the bone.
These above issues are some of the main culprits of aging.
Vitamin K2 Benefits:
- Bone health* [3-7,11]
- Cardiovascular function* [12-16]
- Calcium regulation and homeostasis*
- Dental health* 
- Blood pressure regulation*
- Helps prevent osteo- conditions* [1-2,6]
- Facilitates cellular energy production*
- Protects against soft tissue and arterial calcification* [17-20]
- Improves testosterone production* [8-9]
- Regulates nervous system & brain health*
1. Highly recommended dose of MK4 for osteoporosis.
Bunyaratavej N, Kittimanon N, Jitivirai T, Tongthongthip B. Highly recommended dose of MK4 for osteoporosis. J Med Assoc Thai. 2009 Sep;92 Suppl5:S4-6. PMID: 19894328.
2. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis.
Hart JP, Shearer MJ, Klenerman L, Catterall A, Reeve J, Sambrook PN, Dodds RA, Bitensky L, Chayen J. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. J Clin Endocrinol Metab. 1985 Jun;60(6):1268-9. doi: 10.1210/jcem-60-6-1268. PMID: 3998071.
3. Pleiotropic actions of vitamin K: protector of bone health and beyond?
Kaneki M, Hosoi T, Ouchi Y, Orimo H. Pleiotropic actions of vitamin K: protector of bone health and beyond? Nutrition. 2006 Jul-Aug;22(7-8):845-52. doi: 10.1016/j.nut.2006.05.003. PMID: 16815498.
4. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study.
Nakamura E, Aoki M, Watanabe F, Kamimura A. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. Nutr J. 2014 Aug 27;13:85. doi: 10.1186/1475-2891-13-85. PMID: 25163392
5. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials.
Inaba N, Sato T, Yamashita T. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials. J Nutr Sci Vitaminol (Tokyo). 2015;61(6):471-80. doi: 10.3177/jnsv.61.471. PMID: 26875489.
Shimizu T, Takahata M, Kameda Y, Hamano H, Ito T, Kimura-Suda H, Todoh M, Tadano S, Iwasaki N. Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. Bone. 2014 Jul;64:95-101. doi: 10.1016/j.bone.2014.04.005. Epub 2014 Apr 13. PMID: 24731926.
8. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells.
11. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture.
Hodges SJ, Akesson K, Vergnaud P, Obrant K, Delmas PD. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J Bone Miner Res. 1993 Oct;8(10):1241-5. doi: 10.1002/jbmr.5650081012. PMID: 8256661.
13. The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification.
14. Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study.
15. Role of vitamin K and vitamin K-dependent proteins in vascular calcification
20. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains
21. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant?
Lal, N., Berenjian, A. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant?. Appl Microbiol Biotechnol 104, 2765–2776 (2020).
22. The role of vitamin K in soft-tissue calcification
23. Vitamin K2 and its Impact on Tooth Epigenetics
Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen Submitted: December 28th 2015 Reviewed: December 5th 2016 Published: March 22nd 2017