The Best B Complex on Earth.
Serving size: 2 capsules. 120 capsules per bottle.
Each capsule contains:
B1: Benfotiamine : 50mg
B2: Riboflavin 5-Phosphate: 25mg
B3: Niacinamide : 125mg
B5: Calcium D-Pantothenate: 10mg
B6: Pyridoxal 5-Phosphate: 5mg
B9: L-5-MTHF: 500mcg
B12: Adenosylcobalamin: 500mcg
Non medicinal ingredients: gelatin (bovine), rice hull powder, magnesium stearate.
3RD PARTY LAB TESTED FOR PURITY.
What makes Energi+ unique?
Put simply, Energi+ was formulated with the best and most bioactive forms of the B Vitamins, in amounts that coincide with the bioenergetic perspective of optimizing cellular energy production. No corners were cut with Energi+.
In specific - the following are the major upgrades you get with Energi+, as opposed to other B complex products out there.
1. Thiamine HCl --> Benfotiamine
2. Niacin --> Niacinamide
3. Folic Acid --> L-5-Methyl Folate
4. Methylcobalamin --> Adenosylcobalamin
5. Cellulose capsule --> Bovine gelatin capsule
6. No silicon dioxide, no filler!
B Vitamin Crash Course
The B Vitamins are involved in so many physiological functions, but they are heavily involved and priceless in the context of energy metabolism.
Below is a diagram that illustrates the process of energy production in the cell, and specifically in the mitochondria. It is not all inclusive, but provides a good list of the micronutrients that are required at each step of the energy metabolism process.
Beginning with carbohydrates, proteins, or fats, the body must convert these dietary inputs into Acetyl-CoA, which is what kicks off the energy production process in the mitochondria.
In the mitochondria, The Citric Acid Cycle (TCA) (aka Kreb's Cycle), and the Electron Transport Chain (ETC) are responsible for the majority of our energy (ATP) production.
The important thing to note here is: There are many many steps involved in these energy processes, and each step of the way is facilitated by an enzyme. Enzymes require micronutrients for their function, like Magnesium, Copper, Zinc, Vitamin C, and of course, the B vitamins.
Benfotiamine is a fat-soluble form of Vitamin B1 Thiamine. Benfotiamine has been extensively studied to have a much higher bioavailable capacity than the standard Thiamine HCl. Since it is fat soluble, and not water soluble, it is able to stay in the system for a longer period of time without being excreted. Research suggests it is 3-4x as effective [2,3].
Benfotiamine not only delivers a more bioactive array of benefits from Vitamin B1 around improving glucose utilization, pyruvate dehydrogenase activation, anti-tumor and anti-cancer effects, and neuroprotection [4-7], but also has added benefits of antioxidant and anti-inflammatory effect. It has been shown to reduce DNA damage , and mediate the inflammatory response caused by endotoxin (LPS) and PUFA .
Alcohol and Vitamin B1 have an inverse relationship, and there is evidence to suggest that B1 deficiency caused by alcohol, can cause iron-mediated brain damage . B1 seems to be a very crucial component when it comes to recovering from alcohol use. Benfotiamine has also been shown to have a liver protective effect .
Niacinamide does not need much of an introduction at this point. However, it is important to note that Niacinamide is much preferred over Niacin! Niacin commonly induces a 'flushing' reaction, which is just a nice way of saying inflammatory response .
Not only does Niacinamide not induce this inflammatory response, but it greatly increases our ability to utilize carbohydrates as energy, lowers free fatty acids in the blood, and increases cellular NAD+ levels. These processes make it an incredible tool, especially for someone who needs help switching to a diet with emphasis on burning carbohydrate efficiently as fuel.
Important to note though, is that increased Niacinamide intake also requires an increased demand for the methyl donors . Niacinamide must be methylated and therefore can use up high amounts of methyl donors. These donors are choline, methionine, B9 Folate, and B12. This is why Energi+ contains the most biologically active forms of both B9 and B12.
L5-Methyl Folate (MTHF)
L-5-MTHF is the most biologically active form of folate and is found in nature and in whole foods.
Most supplemental folates are in the form of Folic Acid. The body has to convert folic acid into Methylfolate, and many people struggle with that process due to stress, current biological situation, genetics, and so forth. Unmetabolized folic acid in the body can cause problems [16-17].
L-5-MTHF can support methylation, in tandem with B12, which will not only maximize the efficiency of supplemental Niacinamide, but also helps many other processes such as DNA synthesis, hormone conversion, and homocysteine regulation.
Adenosylcobalamin is the form of B12 that is used directly in the mitochondria to create energy, in the Citric Acid Cycle.
Most B complexes out there contain Methylcobalamin. Similar to L-5-MTHF, the body must convert methylcobalamin into adenosylcobalamin so that it can be used to create energy in the cell [18-19].
This makes Adenosylcobalamin the best choice when it comes to taking a B12 supplement that is going to be easily absorbed by the body, and assist in the energy production process as best possible.
B Vitamin Cheat Sheet:
- Plays a critical role in the metabolism of carbohydrates into energy
- Cofactor for the enzyme Pyruvate Dehydrogenase (PDH)
- PDH is one of the main enzymes that converts glucose from carbohydrate into energy
- Used in synthesis of the neurotransmitter acetylcholine (ACH)
- Improve glucose use
- Required for FAD and FMN which are mitochondrial energy production enzymes
- Assists in carbohydrate, fat, and protein metabolism
- Facilitates the normalization of MTHFR enzyme activity
- Assists glutathione recycling
- Stimulates mitochondrial energy production
- Lowers free fatty acids in the blood
- Assists greatly with carbohydrate metabolism
- Increase NAD+
- May lower cholesterol
B5 Pantothenic Acid
- Energy metabolism
- Synthesis of coenzyme A (Acetyl-CoA - mitochondrial energy molecule!)
- Supports myelin production & neurotransmitter Acetylcholine
- Helps recycle cysteine into glutathione
- Required in monoamine synthesis (dopamine, GABA, serotonin, epinephrines)
- Energy metabolism
- Aids liver detoxification
- Involved in hair, skin, and nail health
- Coenzyme in carboxylation reactions
- Aids insulin production
- Aids aerobic oxidative metabolism
- DNA synthesis & repair
- Amino acid metabolism & conversion
- Homocysteine regulation
- Blood cell production
- Required in rapid cell division & growth
- Can help prevent neural tube defects
- Methylfolate prevents glycine wasting
- New red blood cell production
- Used alongside B9 in homocysteine regulation
- DNA synthesis & repair
- Aids in energy metabolism
- Helps maintain nerve sheaths
- Improves insulin sensitivity
- Aids liver function
- Hormone balance
- Mood improvement
1. Institute of Medicine. 1998. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press. https://doi.org/10.17226/6015.
2. Xie F, Cheng Z, Li S, Liu X, Guo X, Yu P, Gu Z. Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride. J Clin Pharmacol. 2014 Jun;54(6):688-95. doi: 10.1002/jcph.261. Epub 2014 Jan 22. PMID: 24399744.
3. Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. Int J Clin Pharmacol Ther. 1996 Feb;34(2):47-50. PMID: 8929745.
4. Lee BY, Yanamandra K, Bocchini JA Jr. Thiamin deficiency: a possible major cause of some tumors? (review). Oncol Rep. 2005 Dec;14(6):1589-92. PMID: 16273261.
5. Velichko MG, Ostrovskiĭ IuM, Trebukhina RV. Tiamin i obmen piruvata u krys-opukholenositeleĭ [Thiamine and pyruvate metabolism in tumor-bearing rats]. Vopr Med Khim. 1978 Mar-Apr;24(2):220-4. Russian. PMID: 664448.
6. Sambon M, Wins P, Bettendorff L. Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine. Int J Mol Sci. 2021 May 21;22(11):5418. doi: 10.3390/ijms22115418. PMID: 34063830; PMCID: PMC8196556.
7. Hanberry, B.S., Berger, R. & Zastre, J.A. High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate. Cancer Chemother Pharmacol 73, 585–594 (2014). https://doi.org/10.1007/s00280-014-2386-z
8. Schmid U, Stopper H, Heidland A, Schupp N. Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro. Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):371-7. doi: 10.1002/dmrr.860. PMID: 18384109.
9. Shoeb M, Ramana KV. Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med. 2012;52(1):182-190. doi:10.1016/j.freeradbiomed.2011.10.444
10. Fraser, D.A., Hessvik, N.P., Nikolić, N. et al. Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations. Genes Nutr 7, 459–469 (2012). https://doi.org/10.1007/s12263-011-0252-8
11. Aziz, T. Effect of benfotiamine on hepatic tissue levels of free calcium, copper, iron and zinc during CCl4-induced hepatotoxicity in rats. Zanco J. Med. Sci., Vol. 15, No. (2), 2011.
12. Medical University of Vienna. "Vitamin B1 deficiency a key factor in the development of alcohol-related dementia: Hypothesis describes the role of iron deposits in the brain as the cause of dementia in alcoholics." ScienceDaily. ScienceDaily, 9 September 2020.
13. Balakumar P, Rohilla A, Krishan P, Solairaj P, Thangathirupathi A. The multifaceted therapeutic potential of benfotiamine. Pharmacol Res. 2010 Jun;61(6):482-8. doi: 10.1016/j.phrs.2010.02.008. Epub 2010 Feb 25. PMID: 20188835.
14. Kamanna VS, Ganji SH, Kashyap ML. The mechanism and mitigation of niacin-induced flushing. Int J Clin Pract. 2009 Sep;63(9):1369-77. doi: 10.1111/j.1742-1241.2009.02099.x. PMID: 19691622; PMCID: PMC2779993.
15. Sun WP, Li D, Lun YZ, Gong XJ, Sun SX, Guo M, Jing LX, Zhang LB, Xiao FC, Zhou SS. Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives. Hypertens Res. 2012 Feb;35(2):180-5. doi: 10.1038/hr.2011.151. Epub 2011 Sep 15. PMID: 21918528.
16. Henderson AM, Aleliunas RE, Loh SP, Khor GL, Harvey-Leeson S, Glier MB, Kitts DD, Green TJ, Devlin AM. l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women. J Nutr. 2018 Jun 1;148(6):885-890. doi: 10.1093/jn/nxy057. PMID: 29878267.
17. Seremak-Mrozikiewicz A. Metafolina--alternatywa dla suplementacji niedoboru folianów u kobiet ciezarnych [Metafolin--alternative for folate deficiency supplementation in pregnant women]. Ginekol Pol. 2013 Jul;84(7):641-6. Polish. doi: 10.17772/gp/1618. PMID: 24032278.
18. Thakkar K, Billa G. Treatment of vitamin B12 deficiency-methylcobalamine? Cyancobalamine? Hydroxocobalamin?-clearing the confusion. Eur J Clin Nutr. 2015 Jan;69(1):1-2. doi: 10.1038/ejcn.2014.165. Epub 2014 Aug 13. PMID: 25117994.
19. Marsh EN, Meléndez GD. Adenosylcobalamin enzymes: theory and experiment begin to converge. Biochim Biophys Acta. 2012 Nov;1824(11):1154-64. doi: 10.1016/j.bbapap.2012.03.012. Epub 2012 Apr 3. PMID: 22516318; PMCID: PMC3580769.
*These Statements have not been evaluated by the Food and Drug Association, or Health Canada. These products are not meant to diagnose, treat, cure, or prevent any diseases.