Regulate
by LifeBlud
Vitamin K2 Mk4 & Mk7
in their fully bioactive, trans-isomer form [21]. Naturally derived.
Approximately 4 months supply.
Supplement Facts:
Servings per container: 143
Serving size (10 drops):
Mk4 10,000 mcg
Mk7 200 mcg
Other ingredients: MCT oil.
Vitamin K2 is the ultimate calcium regulator.
Calcium regulation is the hallmark of dental, bone, artery, and cell health.
Why?
Because calcium is, of course, an incredibly important mineral in our body and thus to have in our diet as well. BUT, it must be in the right place.
Blood calcium is the main regulator of Parathyroid Hormone (PTH) secretion, which can be thrown off by consuming more phosphorous than calcium (See blog post: 'Meat in Context'). Otherwise, the vast majority of calcium we get should be in the bones. High phosphorous intake, without adequate calcium intake will result in the raise in PTH, causing calcium to be pulled out of the bones, and into the blood. When this becomes chronic, it can result in osteoporosis and other osteo- conditions.
It is the role of both magnesium, and Vitamin K2, to direct calcium into where it belongs.
When calcium is deposited into the soft tissues, the buildup results in soft tissue calcification which can lead to stiff and aching muscles. When calcium is deposited in the blood vessels and arteries, it leads to arterial plaque which can cause serious cardiovascular issues, and high blood pressure,
During stress, calcium floods into the cell and causes cellular inflammation, excitation, and can cause cell death.
Vitamin K2 plays a crucial role in pulling calcium out of the soft tissues, and the arteries, and directing it back into the bone.
These above issues are some of the main culprits of aging.
Vitamin K2 Benefits:
- Bone health* [3-7,11]
- Cardiovascular function* [12-16]
- Calcium regulation and homeostasis*
- Dental health* [23]
- Blood pressure regulation*
- Helps prevent osteo- conditions* [1-2,6]
- Facilitates cellular energy production*
- Protects against soft tissue and arterial calcification* [17-20]
- Improves testosterone production* [8-9]
- Regulates nervous system & brain health*
References
References
1. Highly recommended dose of MK4 for osteoporosis.
Bunyaratavej N, Kittimanon N, Jitivirai T, Tongthongthip B. Highly recommended dose of MK4 for osteoporosis. J Med Assoc Thai. 2009 Sep;92 Suppl5:S4-6. PMID: 19894328.
https://pubmed.ncbi.nlm.nih.gov/19894328
2. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis.
Hart JP, Shearer MJ, Klenerman L, Catterall A, Reeve J, Sambrook PN, Dodds RA, Bitensky L, Chayen J. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. J Clin Endocrinol Metab. 1985 Jun;60(6):1268-9. doi: 10.1210/jcem-60-6-1268. PMID: 3998071.
https://pubmed.ncbi.nlm.nih.gov/3998071
3. Pleiotropic actions of vitamin K: protector of bone health and beyond?
Kaneki M, Hosoi T, Ouchi Y, Orimo H. Pleiotropic actions of vitamin K: protector of bone health and beyond? Nutrition. 2006 Jul-Aug;22(7-8):845-52. doi: 10.1016/j.nut.2006.05.003. PMID: 16815498.
https://pubmed.ncbi.nlm.nih.gov/16815498
4. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study.
Nakamura E, Aoki M, Watanabe F, Kamimura A. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. Nutr J. 2014 Aug 27;13:85. doi: 10.1186/1475-2891-13-85. PMID: 25163392
https://pubmed.ncbi.nlm.nih.gov/25163392
5. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials.
Inaba N, Sato T, Yamashita T. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials. J Nutr Sci Vitaminol (Tokyo). 2015;61(6):471-80. doi: 10.3177/jnsv.61.471. PMID: 26875489.
6. Vitamin K₂ therapy for postmenopausal osteoporosis.
Iwamoto J. Vitamin K₂ therapy for postmenopausal osteoporosis. Nutrients. 2014 May 16;6(5):1971-80. doi: 10.3390/nu6051971. PMID: 24841104; PMCID: PMC4042573.
https://pubmed.ncbi.nlm.nih.gov/24841104
7. Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair.
Shimizu T, Takahata M, Kameda Y, Hamano H, Ito T, Kimura-Suda H, Todoh M, Tadano S, Iwasaki N. Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. Bone. 2014 Jul;64:95-101. doi: 10.1016/j.bone.2014.04.005. Epub 2014 Apr 13. PMID: 24731926.
https://pubmed.ncbi.nlm.nih.gov/24731926/
8. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells.
Ito A, Shirakawa H, Takumi N, Minegishi Y, Ohashi A, Howlader ZH, Ohsaki Y, Sato T, Goto T, Komai M. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. Lipids Health Dis. 2011 Sep 13;10:158. doi: 10.1186/1476-511X-10-158. PMID: 21914161; PMCID: PMC3180407.
https://pubmed.ncbi.nlm.nih.gov/21914161
9. Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis.
Takumi N, Shirakawa H, Ohsaki Y, Ito A, Watanabe T, Giriwono PE, Sato T, Komai M. Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis. Food Funct. 2011 Jul;2(7):406-11. doi: 10.1039/c1fo10058k. Epub 2011 Jun 13. PMID: 21894328.
https://pubmed.ncbi.nlm.nih.gov/21894328
10. Vitamin K and rheumatoid arthritis.
Okamoto H. Vitamin K and rheumatoid arthritis. IUBMB Life. 2008 Jun;60(6):355-61. doi: 10.1002/iub.41. PMID: 18484089.
https://pubmed.ncbi.nlm.nih.gov/18484089
11. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture.
Hodges SJ, Akesson K, Vergnaud P, Obrant K, Delmas PD. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J Bone Miner Res. 1993 Oct;8(10):1241-5. doi: 10.1002/jbmr.5650081012. PMID: 8256661.
https://pubmed.ncbi.nlm.nih.gov/8256661
12. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits.
Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, Mizuno S, Takahashi S, Tajima T, Nakamura T. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997 Oct;75(2):135-43. doi: 10.1254/jjp.75.135. PMID: 9414028.
https://pubmed.ncbi.nlm.nih.gov/9414028
13. The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification.
Mandatori D, Pelusi L, Schiavone V, Pipino C, Di Pietro N, Pandolfi A. The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification. Nutrients. 2021 Apr 7;13(4):1222. doi: 10.3390/nu13041222. PMID: 33917175; PMCID: PMC8067793.
https://pubmed.ncbi.nlm.nih.gov/33917175
14. Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study.
Fusaro M, Noale M, Viola V, Galli F, Tripepi G, Vajente N, Plebani M, Zaninotto M, Guglielmi G, Miotto D, Dalle Carbonare L, D'Angelo A, Naso A, Grimaldi C, Miozzo D, Giannini S, Gallieni M; VItamin K Italian (VIKI) Dialysis Study Investigators. Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study. J Bone Miner Res. 2012 Nov;27(11):2271-8. doi: 10.1002/jbmr.1677. PMID: 22692665.
https://pubmed.ncbi.nlm.nih.gov/22692665/
15. Role of vitamin K and vitamin K-dependent proteins in vascular calcification
Schurgers LJ, Dissel PE, Spronk HM, Soute BA, Dhore CR, Cleutjens JP, Vermeer C. Role of vitamin K and vitamin K-dependent proteins in vascular calcification. Z Kardiol. 2001;90 Suppl 3:57-63. doi: 10.1007/s003920170043. PMID: 11374034.
https://pubmed.ncbi.nlm.nih.gov/11374034
16. Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review)
Wen L, Chen J, Duan L, Li S. Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review). Mol Med Rep. 2018 Jul;18(1):3-15. doi: 10.3892/mmr.2018.8940. Epub 2018 Apr 27. PMID: 29749440; PMCID: PMC6059683.
https://pubmed.ncbi.nlm.nih.gov/29749440
17. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification
Wallin R, Schurgers L, Wajih N. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. Thromb Res. 2008;122(3):411-7. doi: 10.1016/j.thromres.2007.12.005. Epub 2008 Jan 30. PMID: 18234293; PMCID: PMC2529147.
https://pubmed.ncbi.nlm.nih.gov/18234293
18. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats
Spronk HM, Soute BA, Schurgers LJ, Thijssen HH, De Mey JG, Vermeer C. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. J Vasc Res. 2003 Nov-Dec;40(6):531-7. doi: 10.1159/000075344. Epub 2003 Dec 3. PMID: 14654717.
https://pubmed.ncbi.nlm.nih.gov/14654717
19. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits
Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, Mizuno S, Takahashi S, Tajima T, Nakamura T. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997 Oct;75(2):135-43. doi: 10.1254/jjp.75.135. PMID: 9414028.
https://pubmed.ncbi.nlm.nih.gov/9414028
20. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains
Ronden JE, Groenen-van Dooren MM, Hornstra G, Vermeer C. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. Atherosclerosis. 1997 Jul 11;132(1):61-7. doi: 10.1016/s0021-9150(97)00087-7. PMID: 9247360.
https://pubmed.ncbi.nlm.nih.gov/9247360
21. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant?
Lal, N., Berenjian, A. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant?. Appl Microbiol Biotechnol 104, 2765–2776 (2020).
https://link.springer.com/article/10.1007/s00253-020-10409-1
22. The role of vitamin K in soft-tissue calcification
Theuwissen E, Smit E, Vermeer C. The role of vitamin K in soft-tissue calcification. Adv Nutr. 2012 Mar 1;3(2):166-73. doi: 10.3945/an.111.001628. PMID: 22516724; PMCID: PMC3648717.
https://pubmed.ncbi.nlm.nih.gov/22516724
23. Vitamin K2 and its Impact on Tooth Epigenetics
Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen Submitted: December 28th 2015
Reviewed: December 5th 2016 Published: March 22nd 2017
https://www.intechopen.com/books/vitamin-k2-vital-for-health-and-wellbeing/vitamin-k2-and-its-impact-on-tooth-epigenetics
These claims have not been evaluated by Health Canada or the Food and Drug Administration. These products are not intended to diagnose, prevent, heal, or treat any disease.
