Regulate vitamin k2, mk4. mk7 in MCT oil in dropper bottle

Vitamin K2

Regulate

Name: Regulate
Brand: LifeBlud
Price: 66.0 USD
Availability: InStock
Rating: 5.0 (21 reviews)

$66.00 USD

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21 reviews

Vitamin K2 Mk4 & Mk7 liquid.

Fully bioactive, trans-isomer form. Naturally derived. Regulate is in liquid form in an MCT oil base with a dropper for a capsule-free experience.

Supports calcium regulation for optimized dental, bone, and cardiovascular health.

Third-party lab tested for purity.

Supplement Facts

Each bottle contains: 1 oz. (32ml)
Servings per container: 143 - Approximately 4 months supply.

Each serving contains:

Mk4 10,000 mcg
Mk7 200 mcg

Benefits

Bone health* [3-7,11]
Cardiovascular function* [12-16]
Calcium regulation and homeostasis*
Dental health* [23]
Blood pressure regulation*
Helps prevent osteo- conditions* [1-2,6]
Facilitates cellular energy production*
Protects against soft tissue and arterial calcification* [17-20]
Improves testosterone production* [8-9]
Regulates nervous system & brain health*

*These Statements have not been evaluated by the Food and Drug Association, or Health Canada. These products are not meant to diagnose, treat, cure, or prevent any diseases.

How to Take

Take 10 drops daily with food.

Drop onto the gums for optimal absorption.

For an in-depth look at Vitamin K2 and a comparison of MK-Seven and Regulate, check out Vitamin K: A General Guide.

Vitamin K2 is the ultimate calcium regulator.

Calcium regulation is the hallmark of dental, bone, artery, and cell health. Of course, calcium is an incredibly important mineral in our body and thus should be in our diet as well. But it must be in the right place.

Blood calcium is the primary regulator of Parathyroid Hormone (PTH) secretion, which can be thrown off by consuming more phosphorus than calcium (See blog post: 'Meat in Context'). Otherwise, the vast majority of calcium we get should be in the bones.

High phosphorus intake, without adequate calcium intake, will raise PTH, causing calcium to be pulled out of the bones and into the blood. When this becomes chronic, it can result in osteoporosis and other osteo-related conditions.

Both magnesium and Vitamin K2 play the role of directing calcium to where it belongs.

When calcium is deposited into the soft tissues, the buildup results in soft tissue calcification, leading to stiff and aching muscles.

When calcium is deposited in the blood vessels and arteries, it leads to arterial plaque, which can cause serious cardiovascular issues and high blood pressure.

During stress, calcium floods into the cell, causing cellular inflammation, excitation, and even cell death.

Vitamin K2 is crucial in pulling calcium out of the soft tissues and the arteries and directing it back into the bone, preventing harmful buildup.

These above issues are some of the main culprits of aging.

1. Highly recommended dose of MK4 for osteoporosis. Bunyaratavej N, Kittimanon N, Jitivirai T, Tongthongthip B. Highly recommended dose of MK4 for osteoporosis. J Med Assoc Thai. 2009 Sep;92 Suppl5:S4-6. PMID: 19894328. https://pubmed.ncbi.nlm.nih.gov/19894328

2. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. Hart JP, Shearer MJ, Klenerman L, Catterall A, Reeve J, Sambrook PN, Dodds RA, Bitensky L, Chayen J. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. J Clin Endocrinol Metab. 1985 Jun;60(6):1268-9. doi: 10.1210/jcem-60-6-1268. PMID: 3998071. https://pubmed.ncbi.nlm.nih.gov/3998071

3. Pleiotropic actions of vitamin K: protector of bone health and beyond? Kaneki M, Hosoi T, Ouchi Y, Orimo H. Pleiotropic actions of vitamin K: protector of bone health and beyond? Nutrition. 2006 Jul-Aug;22(7-8):845-52. doi: 10.1016/j.nut.2006.05.003. PMID: 16815498.

https://pubmed.ncbi.nlm.nih.gov/16815498

4. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. Nakamura E, Aoki M, Watanabe F, Kamimura A. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. Nutr J. 2014 Aug 27;13:85. doi: 10.1186/1475-2891-13-85. PMID: 25163392 https://pubmed.ncbi.nlm.nih.gov/25163392

5. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials. Inaba N, Sato T, Yamashita T. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials. J Nutr Sci Vitaminol (Tokyo). 2015;61(6):471-80. doi: 10.3177/jnsv.61.471. PMID: 26875489.

6. Vitamin K₂ therapy for postmenopausal osteoporosis. Iwamoto J. Vitamin K₂ therapy for postmenopausal osteoporosis. Nutrients. 2014 May 16;6(5):1971-80. doi: 10.3390/nu6051971. PMID: 24841104; PMCID: PMC4042573. https://pubmed.ncbi.nlm.nih.gov/24841104

7. Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. Shimizu T, Takahata M, Kameda Y, Hamano H, Ito T, Kimura-Suda H, Todoh M, Tadano S, Iwasaki N. Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. Bone. 2014 Jul;64:95-101. doi: 10.1016/j.bone.2014.04.005. Epub 2014 Apr 13. PMID: 24731926.

https://pubmed.ncbi.nlm.nih.gov/24731926/

8. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. Ito A, Shirakawa H, Takumi N, Minegishi Y, Ohashi A, Howlader ZH, Ohsaki Y, Sato T, Goto T, Komai M. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. Lipids Health Dis. 2011 Sep 13;10:158. doi: 10.1186/1476-511X-10-158. PMID: 21914161; PMCID: PMC3180407.

https://pubmed.ncbi.nlm.nih.gov/21914161

9. Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis.

Takumi N, Shirakawa H, Ohsaki Y, Ito A, Watanabe T, Giriwono PE, Sato T, Komai M. Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis. Food Funct. 2011 Jul;2(7):406-11. doi: 10.1039/c1fo10058k. Epub 2011 Jun 13. PMID: 21894328.

https://pubmed.ncbi.nlm.nih.gov/21894328

10. Vitamin K and rheumatoid arthritis. Okamoto H. Vitamin K and rheumatoid arthritis. IUBMB Life. 2008 Jun;60(6):355-61. doi: 10.1002/iub.41. PMID: 18484089.

https://pubmed.ncbi.nlm.nih.gov/18484089

11. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture

Hodges SJ, Akesson K, Vergnaud P, Obrant K, Delmas PD. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J Bone Miner Res. 1993 Oct;8(10):1241-5. doi: 10.1002/jbmr.5650081012. PMID: 8256661.

https://pubmed.ncbi.nlm.nih.gov/8256661

12. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits.

Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, Mizuno S, Takahashi S, Tajima T, Nakamura T. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997 Oct;75(2):135-43. doi: 10.1254/jjp.75.135. PMID: 9414028.

https://pubmed.ncbi.nlm.nih.gov/9414028

13. The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification. Mandatori D, Pelusi L, Schiavone V, Pipino C, Di Pietro N, Pandolfi A. The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification. Nutrients. 2021 Apr 7;13(4):1222. doi: 10.3390/nu13041222. PMID: 33917175; PMCID: PMC8067793.

https://pubmed.ncbi.nlm.nih.gov/33917175

14. Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study.

Fusaro M, Noale M, Viola V, Galli F, Tripepi G, Vajente N, Plebani M, Zaninotto M, Guglielmi G, Miotto D, Dalle Carbonare L, D'Angelo A, Naso A, Grimaldi C, Miozzo D, Giannini S, Gallieni M; VItamin K Italian (VIKI) Dialysis Study Investigators. Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study. J Bone Miner Res. 2012 Nov;27(11):2271-8. doi: 10.1002/jbmr.1677. PMID: 22692665.

https://pubmed.ncbi.nlm.nih.gov/22692665/

15. Role of vitamin K and vitamin K-dependent proteins in vascular calcification Schurgers LJ, Dissel PE, Spronk HM, Soute BA, Dhore CR, Cleutjens JP, Vermeer C. Role of vitamin K and vitamin K-dependent proteins in vascular calcification. Z Kardiol. 2001;90 Suppl 3:57-63. doi: 10.1007/s003920170043. PMID: 11374034.

https://pubmed.ncbi.nlm.nih.gov/11374034

16. Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review) Wen L, Chen J, Duan L, Li S. Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review). Mol Med Rep. 2018 Jul;18(1):3-15. doi: 10.3892/mmr.2018.8940. Epub 2018 Apr 27. PMID: 29749440; PMCID: PMC6059683.

https://pubmed.ncbi.nlm.nih.gov/29749440

17. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification

Wallin R, Schurgers L, Wajih N. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. Thromb Res. 2008;122(3):411-7. doi: 10.1016/j.thromres.2007.12.005. Epub 2008 Jan 30. PMID: 18234293; PMCID: PMC2529147.

https://pubmed.ncbi.nlm.nih.gov/18234293

18. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats Spronk HM, Soute BA, Schurgers LJ, Thijssen HH, De Mey JG, Vermeer C. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. J Vasc Res. 2003 Nov-Dec;40(6):531-7. doi: 10.1159/000075344. Epub 2003 Dec 3. PMID: 14654717.

https://pubmed.ncbi.nlm.nih.gov/14654717

19. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits

https://pubmed.ncbi.nlm.nih.gov/9414028

20. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains Ronden JE, Groenen-van Dooren MM, Hornstra G, Vermeer C. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. Atherosclerosis. 1997 Jul 11;132(1):61-7. doi: 10.1016/s0021-9150(97)00087-7. PMID: 9247360.

https://pubmed.ncbi.nlm.nih.gov/9247360

21. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant? Lal, N., Berenjian, A. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant?. Appl Microbiol Biotechnol 104, 2765–2776 (2020).

https://link.springer.com/article/10.1007/s00253-020-10409-1

22. The role of vitamin K in soft-tissue calcification Theuwissen E, Smit E, Vermeer C. The role of vitamin K in soft-tissue calcification. Adv Nutr. 2012 Mar 1;3(2):166-73. doi: 10.3945/an.111.001628. PMID: 22516724; PMCID: PMC3648717.

https://pubmed.ncbi.nlm.nih.gov/22516724

23. Vitamin K2 and its Impact on Tooth Epigenetics Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen Submitted: December 28th 2015. Reviewed: December 5th 2016 Published: March 22nd 2017 https://www.intechopen.com/books/vitamin-k2-vital-for-health-and-wellbeing/vitamin-k2-and-its-impact-on-tooth-epigenetics

5.0

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Gayle
Verified Buyer
I recommend this product
Rated 5 out of 5 stars
15 seconds ago
Spider Veins Fading!
You get what you pay for! I have used other highly recommended brands of Vit.K but never saw the results with them that I see with Regulate. I started taking Regulate and Antidote (Vit E) together about 6 months ago. I am 70 and I have had terrible spider veins in one ankle for about 29 years that sclerotherapy couldn’t even help. Two months ago I noticed them starting to fade away! I assume due to Regulate. I wish I had before and after pictures. Also my teeth sensitivity is gone. I appreciate the medium as I really dislike taking capsules. I put my powdered and liquid supplements along with Regulate and Antidote and Apple Cider Vinegar in a glass with water. So easy to take that way. No mess. Thank you LifeBud for products that actually work!
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CH
Caroline H.
Verified Buyer
I recommend this product
Rated 5 out of 5 stars
1 month ago
Clean K!
They way I have enjoyed using this product has been targeted for oral health after brushing my teeth and rubbing into my gums
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RW
Robyn W.
Verified Buyer
I recommend this product
Rated 5 out of 5 stars
1 month ago
Staple
One of my staple supplements! I love it
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KS
Katherine S.
Verified Buyer
I recommend this product
Rated 5 out of 5 stars
4 months ago
Great product
Purchased it because it is one of the only formulations I could find with both mk4 and mk7. Have been using it both topically and orally to heal a broken leg (along with magnesium, progesterone, sun, and a ton of milk). Surgeon said 5 weeks until I could walk again, ended up walking after just 2 weeks :) Great product and I appreciate the new dropper lids, I have the old lid version for the progesterone and it gets a bit sticky.
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AM
Anne M.
Verified Buyer
I recommend this product
Rated 5 out of 5 stars
4 months ago
Regulate
Seems great. Easy to take and has an agreeable taste.
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