MAG+

by LifeBlud

$40.00 CAD

Magnesium Taurate + Magnesium Glycinate 
500mg per capsule
120 capsules per bottle

Each capsule contains:
100mg elemental Magnesium
200mg Glycine
200mg Taurine

Other ingredients: bovine gelatin (capsule)


Limited Time: $1 of every product sold will be donated to the independent PhD research of Keith Littlewood (https://keith-littlewood.squarespace.com/) regarding thyroid physiology and disease, specifically the endocrine disrupting environmental pollutants and their effect on thyroid health.


MAG+ - THE BEST ENCAPSULATED MAGNESIUM

Magnesium Taurate and Magnesium Glycinate are considered 'chelated' sources of magnesium - meaning the magnesium molecule is bound to the respective amino acids Taurine or Glycine

This means that we receive the benefit of bioavailable magnesium, and also the benefits of the highly therapeutic amino acids to which they are bound.

The importance of Magnesium:

Magnesium is arguably the main conductor of electricity in the human body, along with water. It has a role in the activation of over 40% of the enzymes in our bodies (3700+), and helps us with many functions including but not limited to:

- synthesize hormones from cholesterol 
- produce energy from the food we eat
- relax our muscles
- lower stress
- sleep restfully
- prevent cramping
- regulate calcium levels
- heart function
- maintain proper blood pressure

Most importantly - magnesium is at the heart of metabolic function. And without proper metabolic function, our bodies become less capable to create energy to perform each and every task they need to do throughout the day.

Magnesium gets depleted under stress, excess sweating, intense exercise, high metabolic activity, low thyroid function, dehydration, and lack of sleep. This is why its so important to replenish magnesium levels daily


Benefits of Taurine: 

Taurine is an amino acid with a long list of impressive benefits. It has been shown to: [3-11]

- thermoregulate (body temperature maintenance)
- balance calcium homeostasis
- improve detoxification
- reduce anxiety
- improve testosterone production
- help maintain electrolyte balance
- regulate blood pressure
- protect from liver damage
- improve glucose levels
- reduce cholesterol levels
- support neurotransmitter production
- protect cognitive function

Benefits of Glycine: 

Glycine is another highly therapeutic amino acid. It is anti-inflammatory, anti-stress, and pro-metabolic. 

Some benefits include: [12-21]

- increasing glutathione
- improved sleep quality
- increase healthy lifespan
- reduces tissue inflammation
- reduces high blood pressure
- collagen production
- liver protective



References:

1. Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-70. doi: 10.1016/j.mehy.2006.01.047. Epub 2006 Mar 20. PMID: 16542786.

2. Uberti F, Morsanuto V, Ruga S, Galla R, Farghali M, Notte F, Bozzo C, Magnani C, Nardone A, Molinari C. Study of Magnesium Formulations on Intestinal Cells to Influence Myometrium Cell Relaxation. Nutrients. 2020 Feb 22;12(2):573. doi: 10.3390/nu12020573. PMID: 32098378; PMCID: PMC7071389.

3. El Idrissi A. Taurine Regulation of Neuroendocrine Function. Adv Exp Med Biol. 2019;1155:977-985. doi: 10.1007/978-981-13-8023-5_81. PMID: 31468461.

4. Zhang CG, Kim SJ. Taurine induces anti-anxiety by activating strychnine-sensitive glycine receptor in vivo. Ann Nutr Metab. 2007;51(4):379-86. doi: 10.1159/000107687. Epub 2007 Aug 29. PMID: 17728537.

5. Li S, Wei BK, Wang J, Dong G, Wang X. Taurine Supplementation Ameliorates Arsenic-Induced Hepatotoxicity and Oxidative Stress in Mouse. Adv Exp Med Biol. 2019;1155:463-470. doi: 10.1007/978-981-13-8023-5_43. PMID: 31468423.

6. Ohsawa Y, Hagiwara H, Nishimatsu SI, Hirakawa A, Kamimura N, Ohtsubo H, Fukai Y, Murakami T, Koga Y, Goto YI, Ohta S, Sunada Y; KN01 Study Group. Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial. J Neurol Neurosurg Psychiatry. 2019 May;90(5):529-536. doi: 10.1136/jnnp-2018-317964. Epub 2018 Apr 17. PMID: 29666206; PMCID: PMC6581075.

7. Waldron M, Patterson SD, Tallent J, Jeffries O. The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis. Sports Med. 2018 May;48(5):1247-1253. doi: 10.1007/s40279-018-0896-2. PMID: 29546641.

8. Ra SG, Choi Y, Akazawa N, Kawanaka K, Ohmori H, Maeda S. Effects of Taurine Supplementation on Vascular Endothelial Function at Rest and After Resistance Exercise. Adv Exp Med Biol. 2019;1155:407-414. doi: 10.1007/978-981-13-8023-5_38. PMID: 31468418.

9. Wen C, Li F, Zhang L, Duan Y, Guo Q, Wang W, He S, Li J, Yin Y. Taurine is Involved in Energy Metabolism in Muscles, Adipose Tissue, and the Liver. Mol Nutr Food Res. 2019 Jan;63(2):e1800536. doi: 10.1002/mnfr.201800536. Epub 2018 Oct 17. PMID: 30251429.

10. Guan L, Miao P. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials. Eur J Pharmacol. 2020 Oct 15;885:173533. doi: 10.1016/j.ejphar.2020.173533. Epub 2020 Aug 29. PMID: 32871172.

11. Bkaily G, Jazzar A, Normand A, Simon Y, Al-Khoury J, Jacques D. Taurine and cardiac disease: state of the art and perspectives. Can J Physiol Pharmacol. 2020 Feb;98(2):67-73. doi: 10.1139/cjpp-2019-0313. PMID: 31560859.

12. Senthilkumar R, Sengottuvelan M, Nalini N. Protective effect of glycine supplementation on the levels of lipid peroxidation and antioxidant enzymes in the erythrocyte of rats with alcohol-induced liver injury. Cell Biochem Funct. 2004 Mar-Apr;22(2):123-8. doi: 10.1002/cbf.1062. PMID: 15027101.

13. Díaz-Flores M, Cruz M, Duran-Reyes G, Munguia-Miranda C, Loza-Rodríguez H, Pulido-Casas E, Torres-Ramírez N, Gaja-Rodriguez O, Kumate J, Baiza-Gutman LA, Hernández-Saavedra D. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure. Can J Physiol Pharmacol. 2013 Oct;91(10):855-60. doi: 10.1139/cjpp-2012-0341. Epub 2013 Jun 17. PMID: 24144057.

14. El Hafidi M, Pérez I, Baños G. Is glycine effective against elevated blood pressure? Curr Opin Clin Nutr Metab Care. 2006 Jan;9(1):26-31. doi: 10.1097/01.mco.0000196143.72985.9a. PMID: 16444815.

15. Koopman R, Caldow MK, Ham DJ, Lynch GS. Glycine metabolism in skeletal muscle: implications for metabolic homeostasis. Curr Opin Clin Nutr Metab Care. 2017 Jul;20(4):237-242. doi: 10.1097/MCO.0000000000000383. PMID: 28375879.

16. Zhang Y, Ma X, Jiang D, Chen J, Jia H, Wu Z, Kim IH, Yang Y. Glycine Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Regulating NLRP3 Inflammasome and NRF2 Signaling. Nutrients. 2020 Feb 26;12(3):611. doi: 10.3390/nu12030611. PMID: 32110933; PMCID: PMC7146254.

17. Oshima S, Shiiya S, Nakamura Y. Combined Supplementation with Glycine and Tryptophan Reduces Purine-Induced Serum Uric Acid Elevation by Accelerating Urinary Uric Acid Excretion: A Randomized, Single-Blind, Placebo-Controlled, Crossover Study. Nutrients. 2019 Oct 23;11(11):2562. doi: 10.3390/nu11112562. PMID: 31652875; PMCID: PMC6893627.

18. Alves A, Bassot A, Bulteau AL, Pirola L, Morio B. Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases. Nutrients. 2019 Jun 16;11(6):1356. doi: 10.3390/nu11061356. PMID: 31208147; PMCID: PMC6627940.

19. Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor F. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Am J Clin Nutr. 2011 Sep;94(3):847-53. doi: 10.3945/ajcn.110.003483. Epub 2011 Jul 27. PMID: 21795440; PMCID: PMC3155927.

20. Razak MA, Begum PS, Viswanath B, Rajagopal S. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxid Med Cell Longev. 2017;2017:1716701. doi: 10.1155/2017/1716701. Epub 2017 Mar 1. PMID: 28337245; PMCID: PMC5350494.

21. Miller RA, Harrison DE, Astle CM, Bogue MA, Brind J, Fernandez E, Flurkey K, Javors M, Ladiges W, Leeuwenburgh C, Macchiarini F, Nelson J, Ryazanov AG, Snyder J, Stearns TM, Vaughan DE, Strong R. Glycine supplementation extends lifespan of male and female mice. Aging Cell. 2019 Jun;18(3):e12953. doi: 10.1111/acel.12953. Epub 2019 Mar 27. PMID: 30916479; PMCID: PMC6516426.


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