Energi+

Each bottle contains: 120 capsules
Servings per bottle: 60

Each capsule contains:
B1: Benfotiamine : 50mg
B2: Riboflavin 5-Phosphate: 25mg
B3: Niacinamide : 125mg
B5: Pantethine: 10mg
B6: Pyridoxal-5-Phosphate : 5mg
B9: L-5-MTHF: 500mcg
B12: Adenosylcobalamin: 500mcg
Biotin: 25mcg
Inositol: 25mg

Non medicinal ingredients: NuRice, gelatin capsule (bovine), NuMag.

*NuRice and NuMag are rice hull products that help us blend the many ingredients of Energi+ together evenly, so each capsule can be filled evenly.

B1 Thiamine

• Plays a critical role in the metabolism of carbohydrates into energy*
• Cofactor for the enzyme Pyruvate Dehydrogenase (PDH)*
• PDH is one of the main enzymes that converts glucose from carbohydrate into energy*
• Used in synthesis of the neurotransmitter acetylcholine (ACH)*
• Improve glucose use*
  

B2 Riboflavin

• Required for FAD and FMN which are mitochondrial energy production enzymes*
• Assists in carbohydrate, fat, and protein metabolism*
• Facilitates the normalization of MTHFR enzyme activity*
• Assists glutathione recycling*

B3 Niacinamide

• Stimulates mitochondrial energy production*
• Lowers free fatty acids in the blood*
• Assists greatly with carbohydrate metabolism*
• Increase NAD+*
• May lower cholesterol*
• Neuroprotection*
  

B5 Pantothenic Acid

• Energy metabolism*
• Synthesis of coenzyme A (Acetyl-CoA - mitochondrial energy molecule!)*
• Supports myelin production & neurotransmitter Acetylcholine*
  

B6 Pyridoxine

• Helps recycle cysteine into glutathione*
• Required in monoamine synthesis (dopamine, GABA, serotonin, epinephrines)*
• Energy metabolism*
• Aids liver detoxification*

B7 Biotin

• Involved in hair, skin, and nail health*
• Coenzyme in carboxylation reactions*
• Aids insulin production*
• Aids aerobic oxidative metabolism*
  

B9 Folate

• DNA synthesis & repair*
• Methylation*
• Amino acid metabolism & conversion*
• Homocysteine regulation*
• Blood cell production*
• Required in rapid cell division & growth*
• Can help prevent neural tube defects*
• Methylfolate prevents glycine wasting*
  

B12 Cobalamin

• New red blood cell production*
• Used alongside B9 in homocysteine regulation*
• DNA synthesis & repair*
• Aids in energy metabolism*
• Helps maintain nerve sheaths*

Inositol

• Improves insulin sensitivity*
• Aids liver function *
• Hormone balance*
• Mood improvement*

*These Statements have not been evaluated by the Food and Drug Association, or Health Canada. These products are not meant to diagnose, treat, cure, or prevent any diseases.

Take 2 capsules daily, at two separate times throughout the day. With food is recommended but not strictly necessary.

The capsules may be opened up and mixed into a beverage to consume gradually through the day.

1. Institute of Medicine. 1998. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press. https://doi.org/10.17226/6015. https://www.nap.edu/read/6015/chapter/1

2. Xie F, Cheng Z, Li S, Liu X, Guo X, Yu P, Gu Z. Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride. J Clin Pharmacol. 2014 Jun;54(6):688-95. doi: 10.1002/jcph.261. Epub 2014 Jan 22. PMID: 24399744. https://pubmed.ncbi.nlm.nih.gov/24399744/

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4. Lee BY, Yanamandra K, Bocchini JA Jr. Thiamin deficiency: a possible major cause of some tumors? (review). Oncol Rep. 2005 Dec;14(6):1589-92. PMID: 16273261. https://pubmed.ncbi.nlm.nih.gov/16273261/

5. siteleĭ [Thiamine and pyruvate Velichko MG, Ostrovskiĭ IuM, Trebukhina RV. Tiamin i obmen piruvata u krys-opukholenometabolism in tumor-bearing rats]. Vopr Med Khim. 1978 Mar-Apr;24(2):220-4. Russian. PMID: 664448. https://pubmed.ncbi.nlm.nih.gov/664448/

6. Sambon M, Wins P, Bettendorff L. Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine. Int J Mol Sci. 2021 May 21;22(11):5418. doi: 10.3390/ijms22115418. PMID: 34063830; PMCID: PMC8196556. https://pubmed.ncbi.nlm.nih.gov/34063830/

7. Hanberry, B.S., Berger, R. & Zastre, J.A. High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate. Cancer Chemother Pharmacol 73, 585–594 (2014). https://doi.org/10.1007/s00280-014-2386-z

8. Schmid U, Stopper H, Heidland A, Schupp N. Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro. Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):371-7. doi: 10.1002/dmrr.860. PMID: 18384109. https://pubmed.ncbi.nlm.nih.gov/18384109/

9. Shoeb M, Ramana KV. Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med. 2012;52(1):182-190. doi:10.1016/j.freeradbiomed.2011.10.444 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249497/

10. Fraser, D.A., Hessvik, N.P., Nikolić, N. et al. Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations. Genes Nutr 7, 459–469 (2012). https://doi.org/10.1007/s12263-011-0252-8 https://genesandnutrition.biomedcentral.com/articles/10.1007/s12263-011-0252-8

11. Aziz, T. Effect of benfotiamine on hepatic tissue levels of free calcium, copper, iron and zinc during CCl4-induced hepatotoxicity in rats. Zanco J. Med. Sci., Vol. 15, No. (2), 2011. https://www.researchgate.net

12. Medical University of Vienna. "Vitamin B1 deficiency a key factor in the development of alcohol-related dementia: Hypothesis describes the role of iron deposits in the brain as the cause of dementia in alcoholics." ScienceDaily. ScienceDaily, 9 September 2020. https://www.sciencedaily.com/releases/2020/09/200909100248.htm

13. Balakumar P, Rohilla A, Krishan P, Solairaj P, Thangathirupathi A. The multifaceted therapeutic potential of benfotiamine. Pharmacol Res. 2010 Jun;61(6):482-8. doi: 10.1016/j.phrs.2010.02.008. Epub 2010 Feb 25. PMID: 20188835. https://pubmed.ncbi.nlm.nih.gov/20188835/

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16. Henderson AM, Aleliunas RE, Loh SP, Khor GL, Harvey-Leeson S, Glier MB, Kitts DD, Green TJ, Devlin AM. l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women. J Nutr. 2018 Jun 1;148(6):885-890. doi: 10.1093/jn/nxy057. PMID: 29878267. https://pubmed.ncbi.nlm.nih.gov/29878267/

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