Energy
Liver Health
Metabolism

Energi+

$36.00 USD

The Best B Complex on Earth

Description

Energi+ uses the most bioactive forms of B vitamins to support cellular energy production, metabolism, and healthy methylation. No cheap substitutes—just premium forms like Benfotiamine, Niacinamide, L-5-MTHF, Adenosylcobalamin, and Pantethine. Third-party lab tested and delivered in a clean bovine gelatin capsule.

Quantity / Bottle

1 Bottle60 day supply$36.00 USD
Save 5%2 Pack120 day supply$72.40 USD
Save 10%3 Pack180 day supply$97.20 USD

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B1 Thiamine

Plays a critical role in the metabolism of carbohydrates into energy*
Cofactor for the enzyme Pyruvate Dehydrogenase (PDH)*
PDH is one of the main enzymes that converts glucose from carbohydrate into energy*
Used in synthesis of the neurotransmitter acetylcholine (ACH)*
Improve glucose use*

B2 Riboflavin

Required for FAD and FMN which are mitochondrial energy production enzymes*
Assists in carbohydrate, fat, and protein metabolism*
Facilitates the normalization of MTHFR enzyme activity*
Assists glutathione recycling*

B3 Niacinamide

Stimulates mitochondrial energy production*
Lowers free fatty acids in the blood*
Assists greatly with carbohydrate metabolism*
Increase NAD+*
May lower cholesterol*
Neuroprotection*

B5 Pantothenic Acid

Energy metabolism*
Synthesis of coenzyme A (Acetyl-CoA - mitochondrial energy molecule!)*
Supports myelin production & neurotransmitter Acetylcholine*

B6 Pyridoxine

Helps recycle cysteine into glutathione*
Required in monoamine synthesis (dopamine, GABA, serotonin, epinephrines)*
Energy metabolism*
Aids liver detoxification*

B7 Biotin

Involved in hair, skin, and nail health*
Coenzyme in carboxylation reactions*
Aids insulin production*
Aids aerobic oxidative metabolism*

B9 Folate

DNA synthesis & repair*
Methylation*
Amino acid metabolism & conversion*
Homocysteine regulation*
Blood cell production*
Required in rapid cell division & growth*
Can help prevent neural tube defects*
Methylfolate prevents glycine wasting*

B12 Cobalamin

New red blood cell production*
Used alongside B9 in homocysteine regulation*
DNA synthesis & repair*
Aids in energy metabolism*
Helps maintain nerve sheaths*

Inositol

Improves insulin sensitivity*
Aids liver function *
Hormone balance*
Mood improvement*

*These Statements have not been evaluated by the Food and Drug Association, or Health Canada. These products are not meant to diagnose, treat, cure, or prevent any diseases.

Each bottle contains: 120 capsules
Servings per bottle: 60

Each capsule contains:
B1: Benfotiamine : 50mg
B2: Riboflavin 5-Phosphate: 25mg
B3: Niacinamide : 125mg
B5: Pantethine: 10mg
B6: Pyridoxal-5-Phosphate : 5mg
B9: L-5-MTHF: 500mcg
B12: Adenosylcobalamin: 500mcg
Biotin: 25mcg
Inositol: 25mg

Non medicinal ingredients: L-Leucine, Gelatin capsule (bovine)

Take 2 capsules daily, at two separate times throughout the day. With food is recommended but not strictly necessary.

The capsules may be opened up and mixed into a beverage to consume gradually through the day.

1. Institute of Medicine. 1998. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press. https://doi.org/10.17226/6015. https://www.nap.edu/read/6015/chapter/1

2. Xie F, Cheng Z, Li S, Liu X, Guo X, Yu P, Gu Z. Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride. J Clin Pharmacol. 2014 Jun;54(6):688-95. doi: 10.1002/jcph.261. Epub 2014 Jan 22. PMID: 24399744. https://pubmed.ncbi.nlm.nih.gov/24399744/

3. Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. Int J Clin Pharmacol Ther. 1996 Feb;34(2):47-50. PMID: 8929745. https://pubmed.ncbi.nlm.nih.gov/8929745/

4. Lee BY, Yanamandra K, Bocchini JA Jr. Thiamin deficiency: a possible major cause of some tumors? (review). Oncol Rep. 2005 Dec;14(6):1589-92. PMID: 16273261. https://pubmed.ncbi.nlm.nih.gov/16273261/

5. siteleĭ [Thiamine and pyruvate Velichko MG, Ostrovskiĭ IuM, Trebukhina RV. Tiamin i obmen piruvata u krys-opukholenometabolism in tumor-bearing rats]. Vopr Med Khim. 1978 Mar-Apr;24(2):220-4. Russian. PMID: 664448. https://pubmed.ncbi.nlm.nih.gov/664448/

6. Sambon M, Wins P, Bettendorff L. Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine. Int J Mol Sci. 2021 May 21;22(11):5418. doi: 10.3390/ijms22115418. PMID: 34063830; PMCID: PMC8196556. https://pubmed.ncbi.nlm.nih.gov/34063830/

7. Hanberry, B.S., Berger, R. & Zastre, J.A. High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate. Cancer Chemother Pharmacol 73, 585–594 (2014). https://doi.org/10.1007/s00280-014-2386-z

8. Schmid U, Stopper H, Heidland A, Schupp N. Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro. Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):371-7. doi: 10.1002/dmrr.860. PMID: 18384109. https://pubmed.ncbi.nlm.nih.gov/18384109/

9. Shoeb M, Ramana KV. Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med. 2012;52(1):182-190. doi:10.1016/j.freeradbiomed.2011.10.444 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249497/

10. Fraser, D.A., Hessvik, N.P., Nikolić, N. et al. Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations. Genes Nutr 7, 459–469 (2012). https://doi.org/10.1007/s12263-011-0252-8 https://genesandnutrition.biomedcentral.com/articles/10.1007/s12263-011-0252-8

11. Aziz, T. Effect of benfotiamine on hepatic tissue levels of free calcium, copper, iron and zinc during CCl4-induced hepatotoxicity in rats. Zanco J. Med. Sci., Vol. 15, No. (2), 2011. https://www.researchgate.net

12. Medical University of Vienna. "Vitamin B1 deficiency a key factor in the development of alcohol-related dementia: Hypothesis describes the role of iron deposits in the brain as the cause of dementia in alcoholics." ScienceDaily. ScienceDaily, 9 September 2020. https://www.sciencedaily.com/releases/2020/09/200909100248.htm

13. Balakumar P, Rohilla A, Krishan P, Solairaj P, Thangathirupathi A. The multifaceted therapeutic potential of benfotiamine. Pharmacol Res. 2010 Jun;61(6):482-8. doi: 10.1016/j.phrs.2010.02.008. Epub 2010 Feb 25. PMID: 20188835. https://pubmed.ncbi.nlm.nih.gov/20188835/

14. Kamanna VS, Ganji SH, Kashyap ML. The mechanism and mitigation of niacin-induced flushing. Int J Clin Pract. 2009 Sep;63(9):1369-77. doi: 10.1111/j.1742-1241.2009.02099.x. PMID: 19691622; PMCID: PMC2779993. https://pubmed.ncbi.nlm.nih.gov/19691622/

15. Sun WP, Li D, Lun YZ, Gong XJ, Sun SX, Guo M, Jing LX, Zhang LB, Xiao FC, Zhou SS. Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives. Hypertens Res. 2012 Feb;35(2):180-5. doi: 10.1038/hr.2011.151. Epub 2011 Sep 15. PMID: 21918528. https://pubmed.ncbi.nlm.nih.gov/21918528/

16. Henderson AM, Aleliunas RE, Loh SP, Khor GL, Harvey-Leeson S, Glier MB, Kitts DD, Green TJ, Devlin AM. l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women. J Nutr. 2018 Jun 1;148(6):885-890. doi: 10.1093/jn/nxy057. PMID: 29878267. https://pubmed.ncbi.nlm.nih.gov/29878267/

17. Seremak-Mrozikiewicz A. Metafolina--alternatywa dla suplementacji niedoboru folianów u kobiet ciezarnych [Metafolin--alternative for folate deficiency supplementation in pregnant women]. Ginekol Pol. 2013 Jul;84(7):641-6. Polish. doi: 10.17772/gp/1618. PMID: 24032278. https://pubmed.ncbi.nlm.nih.gov/24032278/

18. Thakkar K, Billa G. Treatment of vitamin B12 deficiency-methylcobalamine? Cyancobalamine? Hydroxocobalamin?-clearing the confusion. Eur J Clin Nutr. 2015 Jan;69(1):1-2. doi: 10.1038/ejcn.2014.165. Epub 2014 Aug 13. PMID: 25117994. https://pubmed.ncbi.nlm.nih.gov/25117994/

19. Marsh EN, Meléndez GD. Adenosylcobalamin enzymes: theory and experiment begin to converge. Biochim Biophys Acta. 2012 Nov;1824(11):1154-64. doi: 10.1016/j.bbapap.2012.03.012. Epub 2012 Apr 3. PMID: 22516318; PMCID: PMC3580769. https://pubmed.ncbi.nlm.nih.gov/22516318/

Energi+

Main Benefits

B vitamins in their most active form — finally.

More energy

Powers the TCA cycle and electron transport chain — the two primary engines of ATP production.

Better mood & focus

Supports dopamine, GABA, and serotonin synthesis through active B6, B9, and B12.

Faster metabolism

Niacinamide raises NAD+ and improves carbohydrate metabolism without the inflammatory flush.

Methylation support

L-5-MTHF and adenosylcobalamin keep methylation running for DNA repair, detox, and hormone balance.

The Problem

Most B-complexes use forms your body can't fully use.

Standard supplements rely on cheap, inactive forms like folic acid, niacin, and thiamine HCl — which the body must convert before they can do anything. Stress, genetics, and MTHFR variants can block those conversions entirely.

Energi+ bypasses this — using only bioactive forms that work directly at the cellular level, from mitochondrial energy production to neurotransmitter synthesis.

✓Drives ATP synthesis via TCA cycle

✓Raises NAD+ via niacinamide

✓Supports methylation & DNA repair

✓Activates nerve & neurotransmitter function

The Science

Why your cells need Energi+.

01 · The Backstory

B vitamins are the engine of cellular energy.

When we eat carbohydrates, proteins, or fats, the body must convert them into acetyl-CoA — the molecule that kicks off energy production in the mitochondria. From there, the Citric Acid Cycle (TCA / Krebs Cycle) and the Electron Transport Chain (ETC) generate the vast majority of our cellular energy (ATP).

Every step in these processes is driven by an enzyme. And enzymes require micronutrients to function — including Magnesium, Copper, Zinc, Vitamin C, and above all, the B vitamins. Without them, energy production at the cellular level breaks down.

02 · Why Forms Matter

Most B complexes use inferior forms. Here's what we changed.

The form of each B vitamin determines whether the body can actually use it. Most supplements cut corners here. Energi+ doesn't.

Thiamine HCl → Benfotiamine — fat-soluble, stays in the system longer, significantly higher bioavailability
Niacin → Niacinamide — no inflammatory flush, raises NAD+, improves carbohydrate metabolism
Folic Acid → L-5-MTHF — the most bioactive form of folate found in nature; bypasses conversion issues caused by stress, genetics, or MTHFR variants
Methylcobalamin → Adenosylcobalamin — the form of B12 used directly in the mitochondria to produce energy in the Citric Acid Cycle
Cellulose capsule → Bovine gelatin — easier to digest, no fillers, no silicon dioxide

03 · Niacinamide & Methylation

Niacinamide raises NAD+ — but it needs support.

Niacinamide dramatically increases the ability to use carbohydrates as fuel, lowers free fatty acids in the blood, and boosts cellular NAD+ levels. It does not cause the inflammatory flushing reaction associated with standard Niacin.

However, Niacinamide must be methylated to be excreted — which draws heavily on methyl donors: choline, methionine, B9 Folate, and B12. Energi+ includes the most bioactive forms of both B9 and B12 specifically to meet this demand and keep methylation running efficiently.

04 · The B Vitamin Cheat Sheet

What each B vitamin actually does.

B1 Benfotiamine — converts glucose into energy; cofactor for Pyruvate Dehydrogenase (PDH); supports acetylcholine synthesis
B2 Riboflavin — required for mitochondrial energy enzymes FAD & FMN; supports glutathione recycling and MTHFR activity
B3 Niacinamide — stimulates mitochondrial energy production; raises NAD+; supports carbohydrate metabolism and neuroprotection
B5 Pantothenic Acid — synthesises Coenzyme A (Acetyl-CoA), the key mitochondrial energy molecule; supports myelin and acetylcholine
B6 Pyridoxine — required for dopamine, GABA, and serotonin synthesis; supports liver detox and glutathione recycling
B7 Biotin — coenzyme in carboxylation reactions; aids insulin production and aerobic oxidative metabolism
B9 L-5-MTHF — DNA synthesis and repair; methylation; homocysteine regulation; prevents glycine wasting
B12 Adenosylcobalamin — used directly in the mitochondria; supports red blood cell production, nerve sheaths, and DNA synthesis
Inositol — improves insulin sensitivity; supports liver function, hormone balance, and mood

Our Energi+

Benfotiamine (B1) — 1,100%+ bioavailability vs standard thiamine
L-5-MTHF & adenosylcobalamin — active folate and B12, no conversion needed
Niacinamide — NAD+ support without the inflammatory niacin flush
Filler-free, 3rd-party tested, bovine gelatin capsule

Other B-Complex

Thiamine HCl — water-soluble, poorly retained, low tissue levels
Folic acid & methylcobalamin — inactive forms that require further conversion
Niacin — causes inflammatory flushing reaction
Fillers, cellulose capsules, and no purity testing

Add To Cart

› What makes the forms in Energi+ better than a standard B-complex?

Standard B-complexes use cheaper, less active forms the body must convert — like folic acid (vs. methylfolate), methylcobalamin (vs. adenosylcobalamin), and niacin (vs. niacinamide). Energi+ uses the forms already in the active state your body needs, skipping those conversion steps.

› Why niacinamide instead of niacin?

Niacin causes a flushing reaction (an inflammatory response). Niacinamide provides all the energy and NAD+ benefits without the flush, and is especially useful for improving carbohydrate metabolism.

› What is benfotiamine and why is it used?

Benfotiamine is a fat-soluble form of B1 (thiamine). Because it's fat-soluble rather than water-soluble, it stays in the body longer and is absorbed at higher rates than standard thiamine HCl.

› Why does Energi+ include inositol?

Inositol supports insulin sensitivity, liver function, hormone balance, and mood — making it a natural complement to the B vitamins in an energy and metabolic support formula.