TUDCA MAX

Pure TUDCA & Ox Bile Extract. 
Pure, lab-tested TUDCA, combined with Ox Bile extract in a bovine gelatin capsule. 


Supplement Facts:
Servings per container: 30
Serving size: 2 capsules

Each capsule contains:
Tauroursodeoxycholic Acid (TUDCA): 250mg
Ox Bile Extract (45% Cholic Acid): 50mg 

Other ingredients: Gelatin (bovine), NuFlow (rice hull). 


TUDCA & Ox Bile for Liver Support, Bile Flow, Detoxification, and more: 

Tauroursodeoxycholic acid (TUDCA) is a water-soluble, conjugated bile salt. It is produced in the liver using cholesterol, deoxycholate (which is made in the intestine by bacteria and cholic acid), and the amino acid Taurine.

TUDCA is made in small amounts in humans, and in larger amounts in bears and other animals such as bovines. TUDCA taken directly from Bear Bile has been used in Traditional Chinese Medicine for thousands of years to improve eye health. 

While bile acids are known as mild surfactants, amino-acid conjugated bile salts like TUDCA are considered strong surfactants. This is in relation to its action as a detergent for removing stuck and sludgy bile, to emulsify and help us digest fats, and to help us increase bile flow from the gallbladder into the intestine. 

The therapeutic value of TUDCA really centers around this ability to improve bile flow. When we eliminate stuck, old, sludgy bile, and improve the flow of bile, the entirety of the metabolic function in the body is improved.

The liver becomes less congested and thus is able to perform its crucial tasks more efficiently. Fat soluble vitamins are absorbed better, glucose from food intake is converted more efficiently into energy, digestion is improved, and ingested and stored toxins are eliminated more readily via bile. 

Since 80% of thyroid hormone T3 is converted from T4 in the liver, thyroid function is accelerated with the ingestion of TUDCA and thus the improvement of liver function. This becomes a positive feedback loop, because improved thyroid function will in turn improve metabolism, digestion, and overall energetic function. 

TUDCA and Today's Context:

Understanding the liver dysfunction epidemic that is so widespread gives us great insight into the usefulness and therapeutic value of TUDCA supplementation. From highly processed food products, seed and vegetable oil ridden food supply, pesticides, chemical home and commercial cleaning products, alcohol overconsumption, pharmaceutical prescription drugs, ubiquitous xenoestrogens, to polluted air and water, and much more.

All of these toxins that we come into contact with must be processed and deactivated by our liver, and much of them are packaged into the bile by the liver which is then to be excreted via the stool. 

But, when we are faced with such an onslaught of toxins constantly, the liver can become overburdened. When this happens, the bile flow can slow down, and both bile and cholesterol will accumulate, become sludgy, and form stones that cause congestion in the liver ducts and gallbladder.

This process over time causes many of the conventional diseases we are familiar with such as high cholesterol, low thyroid, elevated liver enzymes, low metabolic function, fatty liver, and fibrosis. Furthermore, when the body's #1 detox mechanism is now impaired, it has to store the toxins elsewhere, which is typically in the fat tissue. This creates a domino effect of stubborn obesity, and overall physical toxemia. The body, as one holistic system, then begins to fall further into a state of disease. 

Restoring bile flow and liver function is of the absolute top priority for anyone who has lived through modern contexts such as these. 

Why add Ox Bile? 

Ox Bile provides a full spectrum of bile salts to round out the profile of the supplement, so that the body isn't taking in one and only one type of bile salt. Ox Bile has been used therapeutically for a very long time and may benefit those without a gallbladder, or those with insufficient bile production. 

How to take TUDCA MAX?

Generally, the serving size should be taken on a relatively empty stomach. For some, this can be an hour or two after a meal. Some people may also fare better with taking it well before eating, for example first thing in the morning, 30+ minutes prior to breakfast. It can be split into 2 separate doses throughout the day if desired. 

The reasoning for this, is because bile salts are highly alkaline, and are excreted into the intestine after our food has been acidified by stomach acid. The combination between the acidified food, and the alkaline bile salts are what create the digestion of food, fats, and absorption of vitamins (think of adding baking soda to vinegar). We want to wait to give the food enough time to be acidified, before adding in the alkaline bile salts. 

However, each person is different, and therefore we recommend each person find their optimal dosing and timing methods. 
TUDCA MAX Benefits:

- Liver support & detox
- Improved bile flow
- Improved fat digestion
- Increased fat soluble vitamin absorption
- Supports gut health
- Aids in toxin elimination via bile
- Neuroprotective 
- May assist in dissolving gallstones
- May improve liver and muscle insulin sensitivity
- May reduce elevated liver enzyme markers
- May lower cholesterol
- May reduce cholestasis 
- May improve conditions of liver cirrhosis, fatty liver, and hepatitis


References: 

1. Crosignani A, Battezzati PM, Setchell KD, Invernizzi P, Covini G, Zuin M, Podda M. Tauroursodeoxycholic acid for treatment of primary biliary cirrhosis. A dose-response study. Dig Dis Sci. 1996 Apr;41(4):809-15. doi: 10.1007/BF02213140. PMID: 8674405.

2.  Kars M, Yang L, Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, Klein S. Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes. 2010 Aug;59(8):1899-905. doi: 10.2337/db10-0308. Epub 2010 Jun 3. PMID: 20522594; PMCID: PMC2911053.

3. da-Silva WS, Ribich S, Arrojo e Drigo R, Castillo M, Patti ME, Bianco AC. The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. FEBS Lett. 2011 Feb 4;585(3):539-44. doi: 10.1016/j.febslet.2010.12.044. Epub 2011 Jan 14. PMID: 21237159; PMCID: PMC3133948.

4. Kusaczuk M. Tauroursodeoxycholate-Bile Acid with Chaperoning Activity: Molecular and Cellular Effects and Therapeutic Perspectives. Cells. 2019 Nov 20;8(12):1471. doi: 10.3390/cells8121471. PMID: 31757001; PMCID: PMC6952947.

5. Vang S, Longley K, Steer CJ, Low WC. The Unexpected Uses of Urso- and Tauroursodeoxycholic Acid in the Treatment of Non-liver Diseases. Glob Adv Health Med. 2014 May;3(3):58-69. doi: 10.7453/gahmj.2014.017. PMID: 24891994; PMCID: PMC4030606.

6. Cabrera D, Arab JP, Arrese M. UDCA, NorUDCA, and TUDCA in Liver Diseases: A Review of Their Mechanisms of Action and Clinical Applications. Handb Exp Pharmacol. 2019;256:237-264. doi: 10.1007/164_2019_241. PMID: 31236688.

7. Song M, Zhang F, Fu Y, Yi X, Feng S, Liu Z, Deng D, Yang Q, Yu M, Zhu C, Zhu X, Wang L, Gao P, Shu G, Ma X, Jiang Q, Wang S. Tauroursodeoxycholic acid (TUDCA) improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets. J Anim Sci Biotechnol. 2022 Jun 8;13(1):73. doi: 10.1186/s40104-022-00713-3. PMID: 35672805; PMCID: PMC9175448.

8. Tronstad RR, Berland S, Tjora E, El Jellas K, Aukrust I, Kristensen K, Tveitnes D, Molven A, Marschall HU, Rao A, Dawson PA. Fat Malabsorption and Ursodeoxycholic Acid Treatment in Children With Reduced Organic Solute Transporter-α (SLC51A) Expression. JPGN Rep. 2022 Aug;3(3):e229. doi: 10.1097/pg9.0000000000000229. Epub 2022 Jul 25. PMID: 36148443; PMCID: PMC9491403.

9. Zangerolamo L, Vettorazzi JF, Rosa LRO, Carneiro EM, Barbosa HCL. The bile acid TUDCA and neurodegenerative disorders: An overview. Life Sci. 2021 May 1;272:119252. doi: 10.1016/j.lfs.2021.119252. Epub 2021 Feb 23. PMID: 33636170.

10. Boatright JH, Nickerson JM, Moring AG, Pardue MT. Bile acids in treatment of ocular disease. J Ocul Biol Dis Infor. 2009 Sep;2(3):149-159. doi: 10.1007/s12177-009-9030-x. Epub 2009 Aug 27. PMID: 20046852; PMCID: PMC2798994.