Bone Health
Cardiovascular
Metabolism

MK-Seven

$24.00 USD

Premium Vitamin K2 for Calcium Regulation

Description

Made with clinically studied MenaQ7®, the highest quality naturally fermented MK-7 available. Supports healthy calcium utilization for bone, dental, and cardiovascular health with exceptional purity and bioavailability.

Quantity / Bottle

1 Bottle120 day supply$24.00 USD
Save 5%2 Pack240 day supply$45.60 USD
Save 10%3 Pack360 day supply$64.80 USD

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Bone health* [3-7,11]
Cardiovascular function* [12-16]
Calcium regulation and homeostasis*
Dental health* [23]
Blood pressure regulation*
Helps prevent osteo- conditions* [1-2,6]
Facilitates cellular energy production*
Protects against soft tissue and arterial calcification* [17-20]
Improves testosterone production* [8-9]
Regulates nervous system & brain health*

*These Statements have not been evaluated by the Food and Drug Association, or Health Canada. These products are not meant to diagnose, treat, cure, or prevent any diseases.

Each bottle contains: 120 capsules
Servings per container: 120

Each capsule contains: Vitamin K2 Mk7 (MenaQ7®) 120 mcg

Other ingredients: L-Leucine, Bovine gelatin (capsule)

Take 1 capsule daily with food.

1. Bunyaratavej N, Kittimanon N, Jitivirai T, Tongthongthip B. Highly recommended dose of MK4 for osteoporosis. J Med Assoc Thai. 2009 Sep;92 Suppl5:S4-6. PMID: 19894328.

2. Hart JP, Shearer MJ, Klenerman L, Catterall A, Reeve J, Sambrook PN, Dodds RA, Bitensky L, Chayen J. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. J Clin Endocrinol Metab. 1985 Jun;60(6):1268-9. doi: 10.1210/jcem-60-6-1268. PMID: 3998071.

3. Kaneki M, Hosoi T, Ouchi Y, Orimo H. Pleiotropic actions of vitamin K: protector of bone health and beyond? Nutrition. 2006 Jul-Aug;22(7-8):845-52. doi: 10.1016/j.nut.2006.05.003. PMID: 16815498.

4. Nakamura E, Aoki M, Watanabe F, Kamimura A. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. Nutr J. 2014 Aug 27;13:85. doi: 10.1186/1475-2891-13-85. PMID: 25163392

5. Inaba N, Sato T, Yamashita T. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials. J Nutr Sci Vitaminol (Tokyo). 2015;61(6):471-80. doi: 10.3177/jnsv.61.471. PMID: 26875489.

6. Vitamin K₂ therapy for postmenopausal osteoporosis. Iwamoto J. Vitamin K₂ therapy for postmenopausal osteoporosis. Nutrients. 2014 May 16;6(5):1971-80. doi: 10.3390/nu6051971. PMID: 24841104; PMCID: PMC4042573.

7. Shimizu T, Takahata M, Kameda Y, Hamano H, Ito T, Kimura-Suda H, Todoh M, Tadano S, Iwasaki N. Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. Bone. 2014 Jul;64:95-101. doi: 10.1016/j.bone.2014.04.005. Epub 2014 Apr 13. PMID: 24731926.

8. Ito A, Shirakawa H, Takumi N, Minegishi Y, Ohashi A, Howlader ZH, Ohsaki Y, Sato T, Goto T, Komai M. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. Lipids Health Dis. 2011 Sep 13;10:158. doi: 10.1186/1476-511X-10-158. PMID: 21914161; PMCID: PMC3180407.

9. Takumi N, Shirakawa H, Ohsaki Y, Ito A, Watanabe T, Giriwono PE, Sato T, Komai M. Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis. Food Funct. 2011 Jul;2(7):406-11. doi: 10.1039/c1fo10058k. Epub 2011 Jun 13. PMID: 21894328.

10. Okamoto H. Vitamin K and rheumatoid arthritis. IUBMB Life. 2008 Jun;60(6):355-61. doi: 10.1002/iub.41. PMID: 18484089.

11. Hodges SJ, Akesson K, Vergnaud P, Obrant K, Delmas PD. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J Bone Miner Res. 1993 Oct;8(10):1241-5. doi: 10.1002/jbmr.5650081012. PMID: 8256661.

12. Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, Mizuno S, Takahashi S, Tajima T, Nakamura T. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997 Oct;75(2):135-43. doi: 10.1254/jjp.75.135. PMID: 9414028.

13. Mandatori D, Pelusi L, Schiavone V, Pipino C, Di Pietro N, Pandolfi A. The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification. Nutrients. 2021 Apr 7;13(4):1222. doi: 10.3390/nu13041222. PMID: 33917175; PMCID: PMC8067793.

14. Fusaro M, Noale M, Viola V, Galli F, Tripepi G, Vajente N, Plebani M, Zaninotto M, Guglielmi G, Miotto D, Dalle Carbonare L, D'Angelo A, Naso A, Grimaldi C, Miozzo D, Giannini S, Gallieni M; Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study. J Bone Miner Res. 2012 Nov;27(11):2271-8. doi: 10.1002/jbmr.1677. PMID: 22692665.

15. Schurgers LJ, Dissel PE, Spronk HM, Soute BA, Dhore CR, Cleutjens JP, Vermeer C. Role of vitamin K and vitamin K-dependent proteins in vascular calcification. Z Kardiol. 2001;90 Suppl 3:57-63. doi: 10.1007/s003920170043. PMID: 11374034.

16. Wen L, Chen J, Duan L, Li S. Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review). Mol Med Rep. 2018 Jul;18(1):3-15. doi: 10.3892/mmr.2018.8940. Epub 2018 Apr 27. PMID: 29749440; PMCID: PMC6059683.

17. Wallin R, Schurgers L, Wajih N. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. Thromb Res. 2008;122(3):411-7. doi: 10.1016/j.thromres.2007.12.005. Epub 2008 Jan 30. PMID: 18234293; PMCID: PMC2529147.

18. Spronk HM, Soute BA, Schurgers LJ, Thijssen HH, De Mey JG, Vermeer C. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. J Vasc Res. 2003 Nov-Dec;40(6):531-7. doi: 10.1159/000075344. Epub 2003 Dec 3. PMID: 14654717.

19. Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, Mizuno S, Takahashi S, Tajima T, Nakamura T. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997 Oct;75(2):135-43. doi: 10.1254/jjp.75.135. PMID: 9414028.

20. Ronden JE, Groenen-van Dooren MM, Hornstra G, Vermeer C. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. Atherosclerosis. 1997 Jul 11;132(1):61-7. doi: 10.1016/s0021-9150(97)00087-7. PMID: 9247360.

21. Lal, N., Berenjian, A. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant?. Appl Microbiol Biotechnol 104, 2765–2776 (2020).

22. Theuwissen E, Smit E, Vermeer C. The role of vitamin K in soft-tissue calcification. Adv Nutr. 2012 Mar 1;3(2):166-73. doi: 10.3945/an.111.001628. PMID: 22516724; PMCID: PMC3648717.

23. Vitamin K2 and its Impact on Tooth Epigenetics Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen Submitted: December 28th 2015. Reviewed: December 5th 2016 Published: March 22nd 2017

MK-Seven

Main Benefits

Calcium regulation for bones, arteries, and long-term health.

Stronger bones

Activates osteocalcin to direct calcium back into bone where it builds density and strength.

Healthier arteries

Activates MGP to remove calcium from arterial walls — reducing plaque, stiffness, and cardiovascular risk.

Better dental health

Supports calcium integration into teeth and jaw bone for stronger, more resilient dental tissue.

Less soft tissue buildup

Prevents calcium from accumulating in muscles, joints, and soft tissue where it causes stiffness and inflammation.

The Problem

Misplaced calcium is one of the leading drivers of accelerated aging.

Most Western diets provide far too little Vitamin K2 to fully activate the proteins that regulate calcium — leaving it free to deposit in arteries, soft tissues, and cells where it accelerates aging and cardiovascular disease.

MK-Seven addresses this directly — using MenaQ7® 100% trans-isomer K2 MK-7 to activate Matrix Gla Protein and osteocalcin, the body's primary calcium-directing proteins.

✓Activates Matrix Gla Protein (MGP)

✓Directs calcium into bone via osteocalcin

✓Reduces arterial calcification & stiffness

✓Regulates PTH & bone mineral density

The Science

Why your bones need MK-Seven.

01 · The Backstory

Vitamin K2: the ultimate calcium regulator.

Calcium is essential — but only when it ends up in the right place. The vast majority should be in the bones. When it's not, the downstream consequences affect the teeth, arteries, muscles, and cells.

High phosphorus intake without adequate calcium raises Parathyroid Hormone (PTH), pulling calcium out of bones and into the blood. Over time, this leads to osteoporosis and related conditions.

Vitamin K2 is the body's primary tool for directing calcium back into bone — and out of soft tissues and arterial walls where it doesn't belong.

02 · The Problem

What happens when calcium goes to the wrong place.

Misplaced calcium is one of the leading drivers of accelerated aging. Three primary sites of harmful accumulation:

In soft tissues — stiffness and aching muscles from calcification buildup
In blood vessels and arteries — arterial plaque, reduced elasticity, high blood pressure, and cardiovascular risk
Inside cells during stress — inflammation, cellular excitation, and potential cell death

Vitamin K2 activates Matrix Gla Protein (MGP), the body's most important inhibitor of arterial mineralization — pulling calcium out of where it doesn't belong and directing it back into bone.

03 · The Solution

Introducing MK-Seven.

MK-Seven contains Vitamin K2 MK-7 from MenaQ7® — a naturally fermented, highly pure, allergen-free, all-trans isomer menaquinone-7. Clinically validated and rigorously tested as the highest quality and most bioavailable K2 MK-7 on the market.

It supports calcium regulation for optimised dental, bone, and cardiovascular health. Trans-isomer MK-7 has the longest half-life of any K2 form, meaning a single daily dose maintains consistent circulating levels to activate K2-dependent proteins throughout the body.

Our MK-Seven

MenaQ7® — naturally fermented, clinically validated K2 MK-7
100% trans-isomer — the only biologically active form
Longest circulating half-life of any K2 form — once-daily dosing
Filler-free, bovine gelatin capsule, 3rd-party lab tested

Other K2

Often synthetic K2 with mixed trans/cis isomers
Cis-isomer content reduces biological activity
No clinical validation or purity documentation
Fillers and no third-party contaminant testing

Add To Cart

› Why is calcium regulation so important?

When calcium ends up in the wrong places — arteries, soft tissues, or inside cells — it contributes to arterial plaque, stiff muscles, high blood pressure, and cellular inflammation. K2 is the key signal that tells the body to move it back to bone.

› What does all-trans isomer mean and why does it matter?

K2 exists in trans and cis isomer forms. Only the trans form is biologically active and recognized by the body. Many K2 supplements contain a mix. MK-Seven is verified 100% trans-isomer for maximum effectiveness.

› Should I take K2 if I supplement with calcium or Vitamin D?

Yes — K2 is essential when supplementing D3 or calcium. Without K2, the additional calcium absorbed from D3 may deposit in soft tissues and arteries rather than bones.

› What's the difference between MK-Seven and Regulate?

MK-Seven is MK-7 only in capsule form with a longer half-life, suited for once-daily dosing. Regulate provides both MK-4 and MK-7 in liquid form for those who prefer capsule-free supplementation or want the combined effect of both forms.