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The Estrogen Burden: How Tissue Hypoxia, PUFA, and Serotonin Amplify Estrogen’s Effects

    The Estrogen Burden: How Tissue Hypoxia, PUFA, and Serotonin Amplify Estrogen’s Effects

    Adam Marafioti Feb 9, 2026

    Estrogen is rarely discussed with nuance. In mainstream health conversations, it is often reduced to a single narrative: too much estrogen is bad, too little is bad, and balance is the goal

    Prolactin: The Forgotten Stress Hormone That Disrupts Thyroid, Libido, and Metabolic Stability

      Prolactin: The Forgotten Stress Hormone That Disrupts Thyroid, Libido, and Metabolic Stability

      Adam Marafioti Feb 3, 2026

      Prolactin is almost always discussed in one narrow context: lactation. Outside of pregnancy and breastfeeding, it’s rarely considered relevant, and when it is, it’s often treated as a secondary marker rather than a driver of dysfunction.

      The HPT Axis: How Thyroid Hormone Sets the Baseline for All Steroid Production

        The HPT Axis: How Thyroid Hormone Sets the Baseline for All Steroid Production

        Adam Marafioti Jan 27, 2026

        In the body’s hormonal hierarchy, thyroid hormone sits quietly at the top. It doesn’t get the same attention as cortisol, testosterone, or estrogen, yet it determines whether those hormones can be produced, activated, and used effectively in the first place.

        The Steroid Cascade: How Cholesterol Supports Energy, Mood, and Resilience

          The Steroid Cascade: How Cholesterol Supports Energy, Mood, and Resilience

          Adam Marafioti Jan 21, 2026

          Cholesterol has spent decades being framed as the villain of modern health. It’s been blamed for heart disease, clogged arteries, and premature aging, often without context or nuance.

          The HPG Axis and the Bioenergetic Foundations of Fertility

            The HPG Axis and the Bioenergetic Foundations of Fertility

            Adam Marafioti Jan 19, 2026

            Fertility is often discussed as a localized issue in the ovaries, testes, with sperm count, ovulation timing, or hormone levels on a lab panel. But from a bioenergetic perspective, fertility is not a single-organ function.

            Cortisol vs. Progesterone: The Battle for Metabolic Direction

              Cortisol vs. Progesterone: The Battle for Metabolic Direction

              Adam Marafioti Jan 7, 2026

              Every day, your body is making a quiet decision about which direction it will move: toward repair or breakdown, warmth or cold, stability or reactivity.

              Stress, Estrogen, and Serotonin: The Unholy Trinity of Metabolic Suppression

                Stress, Estrogen, and Serotonin: The Unholy Trinity of Metabolic Suppression

                Adam Marafioti Dec 31, 2025

                In the bioenergetic framework, health is not determined by how hard your body can “push through,” nor is disease something that arrives out of nowhere.

                Restoring Metabolic Rhythm: The Overlooked Power of Daily Consistency

                  Restoring Metabolic Rhythm: The Overlooked Power of Daily Consistency

                  Adam Marafioti Dec 30, 2025

                  We often talk about nutrients, hormones, mitochondria, stress mediators, or biochemical pathways, but underneath all of this lies a more ancient force: the body’s need for stable, predictable patterns of nourishment and energy.

                  PUFAs, Winter, and the Thyroid Slowdown

                    PUFAs, Winter, and the Thyroid Slowdown

                    Adam Marafioti Dec 29, 2025

                    Few things suppress metabolic function as predictably, and as silently, as polyunsaturated fatty acids. And few seasons magnify their effects more dramatically than winter.

                    Protein for Repair: The Metabolic Role of Amino Acids

                      Protein for Repair: The Metabolic Role of Amino Acids

                      Adam Marafioti Dec 23, 2025

                      In the bioenergetic view of health, nutrition is not simply about calories, macronutrient ratios, or hitting arbitrary daily targets.

                      Why Basal Body Temperature Matters More Than Your Blood Test

                        Why Basal Body Temperature Matters More Than Your Blood Test

                        Adam Marafioti Dec 19, 2025

                        If your lab results say you’re “normal” but you still feel cold, tired, foggy, or inflamed there’s a missing piece of your health puzzle. Blood tests are just a snapshot.

                        Understanding Inflammation as an Energy Imbalance

                          Understanding Inflammation as an Energy Imbalance

                          Adam Marafioti Dec 17, 2025

                          We’ve been taught to think of inflammation as the enemy. A rogue immune response. A fire to suppress with drugs or diets. But what if inflammation isn’t the root of the problem, but a signal?

                          Glycine’s Power: The Overlooked Backbone of Energy & Healing

                            Glycine’s Power: The Overlooked Backbone of Energy & Healing

                            Adam Marafioti Dec 16, 2025

                            In the realm of metabolic health, some nutrients scream while others whisper. Magnesium gets the spotlight.

                            Glucose for Energy, Not Fat, Is Your Metabolic Friend

                              Glucose for Energy, Not Fat, Is Your Metabolic Friend

                              Adam Marafioti Dec 15, 2025

                              A comparison of glucose vs. ketones/fats in terms of oxidative stress, energy efficiency, and thyroid health

                              Cut the PUFAs: Why and How to Swap Oils for Metabolic Health

                                Cut the PUFAs: Why and How to Swap Oils for Metabolic Health

                                Adam Marafioti Dec 12, 2025

                                There’s a quiet shift happening in the world of nutrition, and it doesn’t involve counting macros, obsessing over calories, or following the latest influencer’s detox.

                                Sugar Fasting and the Benefits of a High-Carb, Low-Fat Approach to Eating

                                  Sugar Fasting and the Benefits of a High-Carb, Low-Fat Approach to Eating

                                  Adam Marafioti Dec 11, 2025

                                  In a world where the diet pendulum swings between “cut all sugar” and “burn fat as fuel,” a third path is emerging, one that harnesses the bioenergetic truth: you’re better off when your metabolism runs hot, when your thyroid works well, and when your cells hum with stable energy.