Great Product 👍🏼for my 🦷
- Bone Health
- Cardiovascular
- Metabolism
Regulate
Regular price
$66.00 USD
Sale price
$66.00 USD
Premium Vitamin K2 for Calcium Regulation
Description
Regulate combines highly bioavailable MK-4 and MK-7 vitamin K2 in their fully active trans-isomer forms to support healthy calcium utilization, cardiovascular function, and strong bones and teeth. Delivered in a clean MCT oil base with a convenient dropper, naturally derived, third-party tested, and free from unnecessary fillers.
Purchase options
- Bone health* [3-7,11]
- Cardiovascular function* [12-16]
- Calcium regulation and homeostasis*
- Dental health* [23]
- Blood pressure regulation*
- Helps prevent osteo- conditions* [1-2,6]
- Facilitates cellular energy production*
- Protects against soft tissue and arterial calcification* [17-20]
- Improves testosterone production* [8-9]
- Regulates nervous system & brain health*
*These Statements have not been evaluated by the Food and Drug Association, or Health Canada. These products are not meant to diagnose, treat, cure, or prevent any diseases.
Take 10 drops daily with food.
Drop onto the gums for optimal absorption.
1. Highly recommended dose of MK4 for osteoporosis. Bunyaratavej N, Kittimanon N, Jitivirai T, Tongthongthip B. Highly recommended dose of MK4 for osteoporosis. J Med Assoc Thai. 2009 Sep;92 Suppl5:S4-6. PMID: 19894328. https://pubmed.ncbi.nlm.nih.gov/19894328
2. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. Hart JP, Shearer MJ, Klenerman L, Catterall A, Reeve J, Sambrook PN, Dodds RA, Bitensky L, Chayen J. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. J Clin Endocrinol Metab. 1985 Jun;60(6):1268-9. doi: 10.1210/jcem-60-6-1268. PMID: 3998071. https://pubmed.ncbi.nlm.nih.gov/3998071
3. Pleiotropic actions of vitamin K: protector of bone health and beyond? Kaneki M, Hosoi T, Ouchi Y, Orimo H. Pleiotropic actions of vitamin K: protector of bone health and beyond? Nutrition. 2006 Jul-Aug;22(7-8):845-52. doi: 10.1016/j.nut.2006.05.003. PMID: 16815498.
https://pubmed.ncbi.nlm.nih.gov/16815498
4. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. Nakamura E, Aoki M, Watanabe F, Kamimura A. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. Nutr J. 2014 Aug 27;13:85. doi: 10.1186/1475-2891-13-85. PMID: 25163392 https://pubmed.ncbi.nlm.nih.gov/25163392
5. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials. Inaba N, Sato T, Yamashita T. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials. J Nutr Sci Vitaminol (Tokyo). 2015;61(6):471-80. doi: 10.3177/jnsv.61.471. PMID: 26875489.
6. Vitamin K₂ therapy for postmenopausal osteoporosis. Iwamoto J. Vitamin K₂ therapy for postmenopausal osteoporosis. Nutrients. 2014 May 16;6(5):1971-80. doi: 10.3390/nu6051971. PMID: 24841104; PMCID: PMC4042573. https://pubmed.ncbi.nlm.nih.gov/24841104
7. Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. Shimizu T, Takahata M, Kameda Y, Hamano H, Ito T, Kimura-Suda H, Todoh M, Tadano S, Iwasaki N. Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. Bone. 2014 Jul;64:95-101. doi: 10.1016/j.bone.2014.04.005. Epub 2014 Apr 13. PMID: 24731926.
https://pubmed.ncbi.nlm.nih.gov/24731926/
8. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. Ito A, Shirakawa H, Takumi N, Minegishi Y, Ohashi A, Howlader ZH, Ohsaki Y, Sato T, Goto T, Komai M. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. Lipids Health Dis. 2011 Sep 13;10:158. doi: 10.1186/1476-511X-10-158. PMID: 21914161; PMCID: PMC3180407.
https://pubmed.ncbi.nlm.nih.gov/21914161
9. Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis.
Takumi N, Shirakawa H, Ohsaki Y, Ito A, Watanabe T, Giriwono PE, Sato T, Komai M. Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis. Food Funct. 2011 Jul;2(7):406-11. doi: 10.1039/c1fo10058k. Epub 2011 Jun 13. PMID: 21894328.
https://pubmed.ncbi.nlm.nih.gov/21894328
10. Vitamin K and rheumatoid arthritis. Okamoto H. Vitamin K and rheumatoid arthritis. IUBMB Life. 2008 Jun;60(6):355-61. doi: 10.1002/iub.41. PMID: 18484089.
https://pubmed.ncbi.nlm.nih.gov/18484089
11. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture
Hodges SJ, Akesson K, Vergnaud P, Obrant K, Delmas PD. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J Bone Miner Res. 1993 Oct;8(10):1241-5. doi: 10.1002/jbmr.5650081012. PMID: 8256661.
https://pubmed.ncbi.nlm.nih.gov/8256661
12. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits.
Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, Mizuno S, Takahashi S, Tajima T, Nakamura T. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997 Oct;75(2):135-43. doi: 10.1254/jjp.75.135. PMID: 9414028.
https://pubmed.ncbi.nlm.nih.gov/9414028
13. The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification. Mandatori D, Pelusi L, Schiavone V, Pipino C, Di Pietro N, Pandolfi A. The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification. Nutrients. 2021 Apr 7;13(4):1222. doi: 10.3390/nu13041222. PMID: 33917175; PMCID: PMC8067793.
https://pubmed.ncbi.nlm.nih.gov/33917175
14. Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study.
Fusaro M, Noale M, Viola V, Galli F, Tripepi G, Vajente N, Plebani M, Zaninotto M, Guglielmi G, Miotto D, Dalle Carbonare L, D'Angelo A, Naso A, Grimaldi C, Miozzo D, Giannini S, Gallieni M; VItamin K Italian (VIKI) Dialysis Study Investigators. Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study. J Bone Miner Res. 2012 Nov;27(11):2271-8. doi: 10.1002/jbmr.1677. PMID: 22692665.
https://pubmed.ncbi.nlm.nih.gov/22692665/
15. Role of vitamin K and vitamin K-dependent proteins in vascular calcification Schurgers LJ, Dissel PE, Spronk HM, Soute BA, Dhore CR, Cleutjens JP, Vermeer C. Role of vitamin K and vitamin K-dependent proteins in vascular calcification. Z Kardiol. 2001;90 Suppl 3:57-63. doi: 10.1007/s003920170043. PMID: 11374034.
https://pubmed.ncbi.nlm.nih.gov/11374034
16. Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review) Wen L, Chen J, Duan L, Li S. Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review). Mol Med Rep. 2018 Jul;18(1):3-15. doi: 10.3892/mmr.2018.8940. Epub 2018 Apr 27. PMID: 29749440; PMCID: PMC6059683.
https://pubmed.ncbi.nlm.nih.gov/29749440
17. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification
Wallin R, Schurgers L, Wajih N. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. Thromb Res. 2008;122(3):411-7. doi: 10.1016/j.thromres.2007.12.005. Epub 2008 Jan 30. PMID: 18234293; PMCID: PMC2529147.
https://pubmed.ncbi.nlm.nih.gov/18234293
18. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats Spronk HM, Soute BA, Schurgers LJ, Thijssen HH, De Mey JG, Vermeer C. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. J Vasc Res. 2003 Nov-Dec;40(6):531-7. doi: 10.1159/000075344. Epub 2003 Dec 3. PMID: 14654717.
https://pubmed.ncbi.nlm.nih.gov/14654717
19. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits
Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, Mizuno S, Takahashi S, Tajima T, Nakamura T. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997 Oct;75(2):135-43. doi: 10.1254/jjp.75.135. PMID: 9414028.
https://pubmed.ncbi.nlm.nih.gov/9414028
20. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains Ronden JE, Groenen-van Dooren MM, Hornstra G, Vermeer C. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. Atherosclerosis. 1997 Jul 11;132(1):61-7. doi: 10.1016/s0021-9150(97)00087-7. PMID: 9247360.
https://pubmed.ncbi.nlm.nih.gov/9247360
21. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant? Lal, N., Berenjian, A. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant?. Appl Microbiol Biotechnol 104, 2765–2776 (2020).
https://link.springer.com/article/10.1007/s00253-020-10409-1
22. The role of vitamin K in soft-tissue calcification Theuwissen E, Smit E, Vermeer C. The role of vitamin K in soft-tissue calcification. Adv Nutr. 2012 Mar 1;3(2):166-73. doi: 10.3945/an.111.001628. PMID: 22516724; PMCID: PMC3648717.
https://pubmed.ncbi.nlm.nih.gov/22516724
23. Vitamin K2 and its Impact on Tooth Epigenetics Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen Submitted: December 28th 2015. Reviewed: December 5th 2016 Published: March 22nd 2017 https://www.intechopen.com/books/vitamin-k2-vital-for-health-and-wellbeing/vitamin-k2-and-its-impact-on-tooth-epigenetics
Regulate
Regulate
Main Benefits
Full-spectrum K2 — fast acting and long-lasting.
🦴
Stronger bones
MK-4 and MK-7 together activate osteocalcin to continuously direct calcium back into bone and support density.
❤️
Healthier arteries
Activates MGP to clear calcium from arterial walls — reducing plaque, stiffness, and cardiovascular risk.
🧬
Less soft tissue buildup
MK-4's rapid peripheral action targets soft tissue calcification where MK-7 alone can't reach as quickly.
💧
Capsule-free liquid
Dissolved in MCT oil for optimal fat-soluble absorption — no capsules, no fillers, just a clean dropper dose.
The Problem
Misplaced calcium is one of the leading drivers of accelerated aging.
K2 deficiency drives the calcium paradox — too little calcium in bone occurring at the same time as too much in arteries and soft tissue. Most Western diets provide far too little K2 to correct it.
Regulate addresses this directly — combining MK-4 and MK-7 in a fully bioactive, trans-isomer liquid to activate the proteins that regulate calcium across both fast and slow timeframes.
✓Activates Matrix Gla Protein (MGP)
✓Directs calcium into bone via osteocalcin
✓Reduces arterial calcification & stiffness
✓Prevents soft tissue calcium buildup
The Science
Why your body needs Regulate.
The Backstory
Vitamin K2: the ultimate calcium regulator.
Calcium is essential — but only when it ends up in the right place. The vast majority should go to the bones. When it doesn't, the downstream consequences touch the teeth, arteries, muscles, and cells.
High phosphorus intake without adequate calcium raises Parathyroid Hormone (PTH), pulling calcium out of bones and into the blood. Over time, this leads to osteoporosis and related conditions.
Both magnesium and Vitamin K2 direct calcium back where it belongs — K2 by activating the proteins that physically pull calcium out of soft tissues and arterial walls and redirect it into bone. These issues are among the main drivers of accelerated aging.
The Problem
What happens when calcium goes to the wrong place.
Misplaced calcium is one of the leading drivers of accelerated aging. Three primary sites where it accumulates harmfully:
- In soft tissues — stiffness and aching muscles from calcification buildup
- In blood vessels and arteries — arterial plaque, reduced elasticity, high blood pressure, and cardiovascular risk
- Inside cells during stress — cellular inflammation, excitation, and potential cell death
K2 deficiency is responsible for what researchers call the "calcium paradox" — low calcium in bone occurring simultaneously with its accumulation in vessel walls. Vitamin K2 is the key to correcting this imbalance.
The Solution
Introducing Regulate: MK-4 & MK-7 in liquid form.
Regulate combines both Vitamin K2 MK-4 and MK-7 in a single fully bioactive, trans-isomer liquid formula — suspended in an MCT oil base with a dropper for a capsule-free experience.
MK-4 plays a crucial role in rapidly pulling calcium from soft tissues and arteries and directing it back into bone. With a shorter half-life (~6–12 hours), it acts quickly and locally in peripheral tissues. MK-7 circulates longer in the body (~72 hours), maintaining systemic K2 activity and supporting bone mineral density over time. Together, they offer full-spectrum calcium regulation across both short and long timeframes.
Supports optimised dental, bone, and cardiovascular health.
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Not just K2. Regulate.
Our Regulate
- MK-4 + MK-7 combined — fast-acting and long-circulating calcium regulation
- 100% trans-isomer — fully bioactive, naturally derived
- Liquid in MCT oil — optimal fat-soluble absorption, no capsules needed
- 3rd-party tested for bacteria, mold, and heavy metals
Other K2
- MK-7 only — no rapid-acting MK-4 for peripheral tissue
- Often synthetic with mixed trans/cis isomers
- Capsule-bound with poor fat-soluble absorption
- No third-party testing or purity documentation
Common Questions
Questions, answered.
› Why include MK-4 alongside MK-7?
MK-4 and MK-7 have different half-lives and tissue distribution. MK-4 acts faster and is found more in certain tissues like the brain and testes. MK-7 lasts longer in the bloodstream. Together they provide broader and more sustained calcium regulation.
› Why is it in MCT oil?
Vitamin K2 is fat-soluble, meaning it requires fat for absorption. MCT oil is a clean, easily digested fat carrier that enhances bioavailability without the need for a meal.
› Who is this best suited for?
Those who prefer liquid supplements, have difficulty swallowing capsules, or want the broader coverage of both MK-4 and MK-7 in one product.
› When does calcium go to the wrong places and cause harm?
When calcium deposits in arteries it contributes to atherosclerosis and high blood pressure. In soft tissues it causes stiffness and pain. During cellular stress, excess calcium flooding cells can cause inflammation and even cell death.
Customer Reviews
Overall rating: 4.9 / 5 from 29 reviews.
We love this liquid form of K2 since it makes it easy for our kids to take. LifeBlud is one of my favorite supplement brands thanks to their consistency, quality, and integrity as a company.
Allison M. 5/5 Verified
Love this product as part of my prenatal regimen! It is clean and bioavailable. It would take so many leafy greens to get these levels of vitamin K! I recommend taking in the morning because it can cause a little energy boost. On my second bottle!
Victoria J. 5/5 Verified
First bottle Still on the first bottle, ordered January 19th, 2026. Quick and easy to take with breakfast. My blood pressure is now regulated and a normal safe rate. Happy to have finally found a product that works.
Tracy B. 5/5
Reshaping oral cavity My oral cavity changed shaped during an episode of being vegan, causing exposed roots. Although not back to normal yet, I am certain this product is providing the necessary nutrients and I am noticing some improvement. It seems pricy but you only need 10 drops per day so it lasts a long time. I do find the push and twist cap frustrating! Sometimes I can't get it off - not sure why this cap is necessary and maybe it can be modified??
Cheryl S. 4/5
really works This is my 3rd bottle? I've lost count. This really works. I gave some to my mom when her hip was hurting. She took one dose before going to bed and the next day the pain was gone. Vitamin K helps keep calcium in the bone. I like the easy droplet delivery versus taking a pill.
Kate A. 5/5
Order for vitamin K2 Regulate Perfect as always!
Sandrine R. 5/5
I already feel results! This product excellent quality! I have been taking it for almost two weeks and already I am noticing a difference in my energy levels and mood. I am more relaxed and I noticed my tooth pain diminishing! I give this a 10/10 and I will buy it again!
Zaakiya C. 5/5
Spider Veins Fading! You get what you pay for! I have used other highly recommended brands of Vit.K but never saw the results with them that I see with Regulate. I started taking Regulate and Antidote (Vit E) together about 6 months ago. I am 70 and I have had terrible spider veins in one ankle for about 29 years that sclerotherapy couldn’t even help. Two months ago I noticed them starting to fade away! I assume due to Regulate. I wish I had before and after pictures. Also my teeth sensitivity is gone. I appreciate the medium as I really dislike taking capsules. I put my powdered and liquid supplements along with Regulate and Antidote and Apple Cider Vinegar in a glass with water. So easy to take that way. No mess. Thank you LifeBud for products that actually work!
Gayle 5/5
Clean K! They way I have enjoyed using this product has been targeted for oral health after brushing my teeth and rubbing into my gums
Caroline H. 5/5
Staple One of my staple supplements! I love it
Robyn W. 5/5
Great product Purchased it because it is one of the only formulations I could find with both mk4 and mk7. Have been using it both topically and orally to heal a broken leg (along with magnesium, progesterone, sun, and a ton of milk). Surgeon said 5 weeks until I could walk again, ended up walking after just 2 weeks :) Great product and I appreciate the new dropper lids, I have the old lid version for the progesterone and it gets a bit sticky.
Katherine S. 5/5
Regulate Seems great. Easy to take and has an agreeable taste.
Anne M. 5/5
Regulate I don't know if this will continue but since starting Regulate the everyday pain in my back has diminished greatly. I have tried other Vitamin K supplements with no effects.
Linda C. 5/5
Eliminated my tooth sensitivity I’ve had very sensitive teeth since giving birth to my second child in 2021. When I started taking this supplement regularly I noticed my sensitivity decreased. I ran out for a while when it was out of stock and my tooth sensitivity came back. Within a week of taking it again, it was gone.
Olivia 5/5
Review of Regulate March 2024 I have been on it for a week so I am feeling ok but not on long enough to know any big differences. I am having blood work done in a couple of weeks, so I will stay on it until then. My Vit D levels were 45 last blood work and I am hoping this will help me to bring those levels up to 70+ and into the normal range. I have a DNA SNP on Vit D Taq and therefore have always had very low Vit D levels. Only once i was normal after a 2 week vacation in Hawaii where i was in the sun all day. I was up to 79 after that but it didn't last long. That is the highest Vit D level that i am aware of in the the past 20 years. i am also using UVB blue room and getting a bit of color from it, so am hoping my levels of Vit D are being enhanced with both of these remedies. Thank you for a wonderful product with no additives. I am chemical sensitive also and grateful to buy PURE product. Cheers, Colleen
Colleen C. 5/5
Great Product Love that the taste is minimal, even my toddler accepts it! I haven’t seen yet such concentrated Vit K ! Will be buying again!
Lia C. 5/5
Haven’t been taking it to long I don’t take this on a daily basis. Have not been taking it long enough to say if it is helping or not.
Tracy M. 4/5
👍👍 Just like all of the other Lifeblud supplements… do your market research and try to find a better deal than them! Quantity and quality.
Taylor A. 5/5
Love Love these vitamin k drops.. perfect for giving to my kids. Oddly enough every time my teeth start bothering me, I realize I haven’t taken these in awhile and after starting back up my teeth feel better! Also the owner of this company is super kind
Gina D. 5/5
Love this product! I like that I can use the liquid option for my child! She hasn’t had a new cavity since Ive started using this for her!
Lauren R. 5/5
Great company All their products are well thought out and have good ingredients. For example, the oil used in Regulate to carry the K2 is MCT oil whereas other brands use oils like sunflower or safflower which are easily oxidized oils that can cause inflammation in the body among other things
George S. 5/5
Excellent product. A regulate grading what? The portions or the in take? I take 10 to 15 drops daily.
Ruth A. 5/5
Perfect Vit K It tastes good, easy to take, and Regulate has both K1 and 2. We want to make sure our calcium goes to the Right place not to our hearts or brains! I’ve been talking for months now. Thank you Adam! Also love the studies you sent via email
Kelly D. 5/5
Great taste So far I'm using it to help prevent and treat cavities in my son so it's too soon to tell if it helps with that specific issue. But it has zero taste and I've tried some weird vit k before with lemon flavour and super thick. This can be added to a drink and you can't even taste it. I like to put it directly into the mouth while eating.
Stepanida B. 5/5
Ease of use The fact that it has no taste and I can mix it into my morning mix of other supplements and electrolytes
Danite C. 5/5
Love this Great long lasting and pure!
Annie V. 5/5
A Real K In Canada ! I think everyone needs K and this product beats any other.
Don P. 5/5
Everyone needs some K I love that this is in liquid form as I already take multiple supplements in capsule form. The liquid is just easier, love the quality of the products, I appreciate that the price point is better than a lot of places as well. Highly recommend! I’m talking this for dental health after a few years of veganism, how did I get any K before this? I didn’t. That’s why my teeth started breaking so now I’m undoing the damage and giving my body what it needs.
Amanda 5/5