Bone Health
Cardiovascular
Metabolism

Regulate

Name: Regulate
Brand: LifeBlud
SKU: L-004
Price: 66.00 USD
Availability: InStock

$66.00 USD

Premium Vitamin K2 for Calcium Regulation

Description

Regulate combines highly bioavailable MK-4 and MK-7 vitamin K2 in their fully active trans-isomer forms to support healthy calcium utilization, cardiovascular function, and strong bones and teeth. Delivered in a clean MCT oil base with a convenient dropper, naturally derived, third-party tested, and free from unnecessary fillers.

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Bone health* [3-7,11]
Cardiovascular function* [12-16]
Calcium regulation and homeostasis*
Dental health* [23]
Blood pressure regulation*
Helps prevent osteo- conditions* [1-2,6]
Facilitates cellular energy production*
Protects against soft tissue and arterial calcification* [17-20]
Improves testosterone production* [8-9]
Regulates nervous system & brain health*

*These Statements have not been evaluated by the Food and Drug Association, or Health Canada. These products are not meant to diagnose, treat, cure, or prevent any diseases.

Take 10 drops daily with food.

Drop onto the gums for optimal absorption.

1. Highly recommended dose of MK4 for osteoporosis. Bunyaratavej N, Kittimanon N, Jitivirai T, Tongthongthip B. Highly recommended dose of MK4 for osteoporosis. J Med Assoc Thai. 2009 Sep;92 Suppl5:S4-6. PMID: 19894328. https://pubmed.ncbi.nlm.nih.gov/19894328

2. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. Hart JP, Shearer MJ, Klenerman L, Catterall A, Reeve J, Sambrook PN, Dodds RA, Bitensky L, Chayen J. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. J Clin Endocrinol Metab. 1985 Jun;60(6):1268-9. doi: 10.1210/jcem-60-6-1268. PMID: 3998071. https://pubmed.ncbi.nlm.nih.gov/3998071

3. Pleiotropic actions of vitamin K: protector of bone health and beyond? Kaneki M, Hosoi T, Ouchi Y, Orimo H. Pleiotropic actions of vitamin K: protector of bone health and beyond? Nutrition. 2006 Jul-Aug;22(7-8):845-52. doi: 10.1016/j.nut.2006.05.003. PMID: 16815498.

https://pubmed.ncbi.nlm.nih.gov/16815498

4. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. Nakamura E, Aoki M, Watanabe F, Kamimura A. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. Nutr J. 2014 Aug 27;13:85. doi: 10.1186/1475-2891-13-85. PMID: 25163392 https://pubmed.ncbi.nlm.nih.gov/25163392

5. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials. Inaba N, Sato T, Yamashita T. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials. J Nutr Sci Vitaminol (Tokyo). 2015;61(6):471-80. doi: 10.3177/jnsv.61.471. PMID: 26875489.

6. Vitamin K₂ therapy for postmenopausal osteoporosis. Iwamoto J. Vitamin K₂ therapy for postmenopausal osteoporosis. Nutrients. 2014 May 16;6(5):1971-80. doi: 10.3390/nu6051971. PMID: 24841104; PMCID: PMC4042573. https://pubmed.ncbi.nlm.nih.gov/24841104

7. Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. Shimizu T, Takahata M, Kameda Y, Hamano H, Ito T, Kimura-Suda H, Todoh M, Tadano S, Iwasaki N. Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. Bone. 2014 Jul;64:95-101. doi: 10.1016/j.bone.2014.04.005. Epub 2014 Apr 13. PMID: 24731926.

https://pubmed.ncbi.nlm.nih.gov/24731926/

8. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. Ito A, Shirakawa H, Takumi N, Minegishi Y, Ohashi A, Howlader ZH, Ohsaki Y, Sato T, Goto T, Komai M. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. Lipids Health Dis. 2011 Sep 13;10:158. doi: 10.1186/1476-511X-10-158. PMID: 21914161; PMCID: PMC3180407.

https://pubmed.ncbi.nlm.nih.gov/21914161

9. Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis.

Takumi N, Shirakawa H, Ohsaki Y, Ito A, Watanabe T, Giriwono PE, Sato T, Komai M. Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis. Food Funct. 2011 Jul;2(7):406-11. doi: 10.1039/c1fo10058k. Epub 2011 Jun 13. PMID: 21894328.

https://pubmed.ncbi.nlm.nih.gov/21894328

10. Vitamin K and rheumatoid arthritis. Okamoto H. Vitamin K and rheumatoid arthritis. IUBMB Life. 2008 Jun;60(6):355-61. doi: 10.1002/iub.41. PMID: 18484089.

https://pubmed.ncbi.nlm.nih.gov/18484089

11. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture

Hodges SJ, Akesson K, Vergnaud P, Obrant K, Delmas PD. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J Bone Miner Res. 1993 Oct;8(10):1241-5. doi: 10.1002/jbmr.5650081012. PMID: 8256661.

https://pubmed.ncbi.nlm.nih.gov/8256661

12. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits.

Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, Mizuno S, Takahashi S, Tajima T, Nakamura T. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997 Oct;75(2):135-43. doi: 10.1254/jjp.75.135. PMID: 9414028.

https://pubmed.ncbi.nlm.nih.gov/9414028

13. The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification. Mandatori D, Pelusi L, Schiavone V, Pipino C, Di Pietro N, Pandolfi A. The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification. Nutrients. 2021 Apr 7;13(4):1222. doi: 10.3390/nu13041222. PMID: 33917175; PMCID: PMC8067793.

https://pubmed.ncbi.nlm.nih.gov/33917175

14. Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study.

Fusaro M, Noale M, Viola V, Galli F, Tripepi G, Vajente N, Plebani M, Zaninotto M, Guglielmi G, Miotto D, Dalle Carbonare L, D'Angelo A, Naso A, Grimaldi C, Miozzo D, Giannini S, Gallieni M; VItamin K Italian (VIKI) Dialysis Study Investigators. Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study. J Bone Miner Res. 2012 Nov;27(11):2271-8. doi: 10.1002/jbmr.1677. PMID: 22692665.

https://pubmed.ncbi.nlm.nih.gov/22692665/

15. Role of vitamin K and vitamin K-dependent proteins in vascular calcification Schurgers LJ, Dissel PE, Spronk HM, Soute BA, Dhore CR, Cleutjens JP, Vermeer C. Role of vitamin K and vitamin K-dependent proteins in vascular calcification. Z Kardiol. 2001;90 Suppl 3:57-63. doi: 10.1007/s003920170043. PMID: 11374034.

https://pubmed.ncbi.nlm.nih.gov/11374034

16. Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review) Wen L, Chen J, Duan L, Li S. Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review). Mol Med Rep. 2018 Jul;18(1):3-15. doi: 10.3892/mmr.2018.8940. Epub 2018 Apr 27. PMID: 29749440; PMCID: PMC6059683.

https://pubmed.ncbi.nlm.nih.gov/29749440

17. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification

Wallin R, Schurgers L, Wajih N. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. Thromb Res. 2008;122(3):411-7. doi: 10.1016/j.thromres.2007.12.005. Epub 2008 Jan 30. PMID: 18234293; PMCID: PMC2529147.

https://pubmed.ncbi.nlm.nih.gov/18234293

18. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats Spronk HM, Soute BA, Schurgers LJ, Thijssen HH, De Mey JG, Vermeer C. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. J Vasc Res. 2003 Nov-Dec;40(6):531-7. doi: 10.1159/000075344. Epub 2003 Dec 3. PMID: 14654717.

https://pubmed.ncbi.nlm.nih.gov/14654717

19. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits

https://pubmed.ncbi.nlm.nih.gov/9414028

20. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains Ronden JE, Groenen-van Dooren MM, Hornstra G, Vermeer C. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. Atherosclerosis. 1997 Jul 11;132(1):61-7. doi: 10.1016/s0021-9150(97)00087-7. PMID: 9247360.

https://pubmed.ncbi.nlm.nih.gov/9247360

21. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant? Lal, N., Berenjian, A. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant?. Appl Microbiol Biotechnol 104, 2765–2776 (2020).

https://link.springer.com/article/10.1007/s00253-020-10409-1

22. The role of vitamin K in soft-tissue calcification Theuwissen E, Smit E, Vermeer C. The role of vitamin K in soft-tissue calcification. Adv Nutr. 2012 Mar 1;3(2):166-73. doi: 10.3945/an.111.001628. PMID: 22516724; PMCID: PMC3648717.

https://pubmed.ncbi.nlm.nih.gov/22516724

23. Vitamin K2 and its Impact on Tooth Epigenetics Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen Submitted: December 28th 2015. Reviewed: December 5th 2016 Published: March 22nd 2017 https://www.intechopen.com/books/vitamin-k2-vital-for-health-and-wellbeing/vitamin-k2-and-its-impact-on-tooth-epigenetics

Regulate

Main Benefits

Full-spectrum K2 — fast acting and long-lasting.

Stronger bones

MK-4 and MK-7 together activate osteocalcin to continuously direct calcium back into bone and support density.

Healthier arteries

Activates MGP to clear calcium from arterial walls — reducing plaque, stiffness, and cardiovascular risk.

Less soft tissue buildup

MK-4's rapid peripheral action targets soft tissue calcification where MK-7 alone can't reach as quickly.

Capsule-free liquid

Dissolved in MCT oil for optimal fat-soluble absorption — no capsules, no fillers, just a clean dropper dose.

The Problem

Misplaced calcium is one of the leading drivers of accelerated aging.

K2 deficiency drives the calcium paradox — too little calcium in bone occurring at the same time as too much in arteries and soft tissue. Most Western diets provide far too little K2 to correct it.

Regulate addresses this directly — combining MK-4 and MK-7 in a fully bioactive, trans-isomer liquid to activate the proteins that regulate calcium across both fast and slow timeframes.

✓Activates Matrix Gla Protein (MGP)

✓Directs calcium into bone via osteocalcin

✓Reduces arterial calcification & stiffness

✓Prevents soft tissue calcium buildup

The Science

Why your body needs Regulate.

The Backstory

Vitamin K2: the ultimate calcium regulator.

Calcium is essential — but only when it ends up in the right place. The vast majority should go to the bones. When it doesn't, the downstream consequences touch the teeth, arteries, muscles, and cells.

High phosphorus intake without adequate calcium raises Parathyroid Hormone (PTH), pulling calcium out of bones and into the blood. Over time, this leads to osteoporosis and related conditions.

Both magnesium and Vitamin K2 direct calcium back where it belongs — K2 by activating the proteins that physically pull calcium out of soft tissues and arterial walls and redirect it into bone. These issues are among the main drivers of accelerated aging.

The Problem

What happens when calcium goes to the wrong place.

Misplaced calcium is one of the leading drivers of accelerated aging. Three primary sites where it accumulates harmfully:

In soft tissues — stiffness and aching muscles from calcification buildup
In blood vessels and arteries — arterial plaque, reduced elasticity, high blood pressure, and cardiovascular risk
Inside cells during stress — cellular inflammation, excitation, and potential cell death

K2 deficiency is responsible for what researchers call the "calcium paradox" — low calcium in bone occurring simultaneously with its accumulation in vessel walls. Vitamin K2 is the key to correcting this imbalance.

The Solution

Introducing Regulate: MK-4 & MK-7 in liquid form.

Regulate combines both Vitamin K2 MK-4 and MK-7 in a single fully bioactive, trans-isomer liquid formula — suspended in an MCT oil base with a dropper for a capsule-free experience.

MK-4 plays a crucial role in rapidly pulling calcium from soft tissues and arteries and directing it back into bone. With a shorter half-life (~6–12 hours), it acts quickly and locally in peripheral tissues. MK-7 circulates longer in the body (~72 hours), maintaining systemic K2 activity and supporting bone mineral density over time. Together, they offer full-spectrum calcium regulation across both short and long timeframes.

Supports optimised dental, bone, and cardiovascular health.

Our Regulate

MK-4 + MK-7 combined — fast-acting and long-circulating calcium regulation
100% trans-isomer — fully bioactive, naturally derived
Liquid in MCT oil — optimal fat-soluble absorption, no capsules needed
3rd-party tested for bacteria, mold, and heavy metals

Other K2

MK-7 only — no rapid-acting MK-4 for peripheral tissue
Often synthetic with mixed trans/cis isomers
Capsule-bound with poor fat-soluble absorption
No third-party testing or purity documentation

Add To Cart

› Why include MK-4 alongside MK-7?

MK-4 and MK-7 have different half-lives and tissue distribution. MK-4 acts faster and is found more in certain tissues like the brain and testes. MK-7 lasts longer in the bloodstream. Together they provide broader and more sustained calcium regulation.

› Why is it in MCT oil?

Vitamin K2 is fat-soluble, meaning it requires fat for absorption. MCT oil is a clean, easily digested fat carrier that enhances bioavailability without the need for a meal.

› Who is this best suited for?

Those who prefer liquid supplements, have difficulty swallowing capsules, or want the broader coverage of both MK-4 and MK-7 in one product.

› When does calcium go to the wrong places and cause harm?

When calcium deposits in arteries it contributes to atherosclerosis and high blood pressure. In soft tissues it causes stiffness and pain. During cellular stress, excess calcium flooding cells can cause inflammation and even cell death.