Regulate vitamin k2, mk4. mk7 in MCT oil in dropper bottle
    Regulate vitamin k2, mk4. mk7 in MCT oil in dropper bottle
    Regulate vitamin k2, mk4. mk7 in MCT oil in dropper bottle
    Regulate vitamin k2, mk4. mk7 in MCT oil in dropper bottle
    Regulate vitamin k2, mk4. mk7 in MCT oil in dropper bottle
    Regulate vitamin k2, mk4. mk7 in MCT oil in dropper bottle

Vitamin K2

Regulate

$66.00 USD
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15 reviews

Vitamin K2 Mk4 & Mk7 liquid.

Fully bioactive, trans-isomer form. Naturally derived. Regulate is in liquid form in an MCT oil base with a dropper for a capsule-free experience.

Supports calcium regulation for optimized dental, bone, and cardiovascular health. 

Third-party lab tested for purity.

Supplement Facts

Each bottle contains: 1 oz. (32ml)
Servings per container: 143 - Approximately 4 months supply.

Each serving contains:

Mk4 10,000 mcg 
Mk7 200 mcg

Benefits

  • Bone health*  [3-7,11]
  • Cardiovascular function*   [12-16]
  • Calcium regulation and homeostasis*
  • Dental health* [23]
  • Blood pressure regulation*
  • Helps prevent osteo- conditions*  [1-2,6]
  • Facilitates cellular energy production*
  • Protects against soft tissue and arterial calcification*  [17-20]
  • Improves testosterone production*  [8-9]
  • Regulates nervous system & brain health*

    *These Statements have not been evaluated by the Food and Drug Association, or Health Canada. These products are not meant to diagnose, treat, cure, or prevent any diseases.

How to Take

Take 10 drops daily with food.

Drop onto the gums for optimal absorption.

For an in-depth look at Vitamin K2 and a comparison of MK-Seven and Regulate, check out Vitamin K: A General Guide.

Vitamin K2 is the ultimate calcium regulator.

Calcium regulation is the hallmark of dental, bone, artery, and cell health. Of course, calcium is an incredibly important mineral in our body and thus should be in our diet as well. But it must be in the right place.

Blood calcium is the primary regulator of Parathyroid Hormone (PTH) secretion, which can be thrown off by consuming more phosphorus than calcium (See blog post: 'Meat in Context'). Otherwise, the vast majority of calcium we get should be in the bones. 

High phosphorus intake, without adequate calcium intake, will raise PTH, causing calcium to be pulled out of the bones and into the blood. When this becomes chronic, it can result in osteoporosis and other osteo-related conditions.

Both magnesium and Vitamin K2 play the role of directing calcium to where it belongs.

When calcium is deposited into the soft tissues, the buildup results in soft tissue calcification, leading to stiff and aching muscles. 

When calcium is deposited in the blood vessels and arteries, it leads to arterial plaque, which can cause serious cardiovascular issues and high blood pressure.

During stress, calcium floods into the cell, causing cellular inflammation, excitation, and even cell death. 

Vitamin K2 is crucial in pulling calcium out of the soft tissues and the arteries and directing it back into the bone, preventing harmful buildup. 

These above issues are some of the main culprits of aging. 

1. Highly recommended dose of MK4 for osteoporosis. Bunyaratavej N, Kittimanon N, Jitivirai T, Tongthongthip B. Highly recommended dose of MK4 for osteoporosis. J Med Assoc Thai. 2009 Sep;92 Suppl5:S4-6. PMID: 19894328. https://pubmed.ncbi.nlm.nih.gov/19894328

2. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. Hart JP, Shearer MJ, Klenerman L, Catterall A, Reeve J, Sambrook PN, Dodds RA, Bitensky L, Chayen J. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. J Clin Endocrinol Metab. 1985 Jun;60(6):1268-9. doi: 10.1210/jcem-60-6-1268. PMID: 3998071. https://pubmed.ncbi.nlm.nih.gov/3998071

3. Pleiotropic actions of vitamin K: protector of bone health and beyond? Kaneki M, Hosoi T, Ouchi Y, Orimo H. Pleiotropic actions of vitamin K: protector of bone health and beyond? Nutrition. 2006 Jul-Aug;22(7-8):845-52. doi: 10.1016/j.nut.2006.05.003. PMID: 16815498.

https://pubmed.ncbi.nlm.nih.gov/16815498

4. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. Nakamura E, Aoki M, Watanabe F, Kamimura A. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. Nutr J. 2014 Aug 27;13:85. doi: 10.1186/1475-2891-13-85. PMID: 25163392 https://pubmed.ncbi.nlm.nih.gov/25163392

5. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials. Inaba N, Sato T, Yamashita T. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials. J Nutr Sci Vitaminol (Tokyo). 2015;61(6):471-80. doi: 10.3177/jnsv.61.471. PMID: 26875489.

6. Vitamin K₂ therapy for postmenopausal osteoporosis. Iwamoto J. Vitamin K₂ therapy for postmenopausal osteoporosis. Nutrients. 2014 May 16;6(5):1971-80. doi: 10.3390/nu6051971. PMID: 24841104; PMCID: PMC4042573. https://pubmed.ncbi.nlm.nih.gov/24841104

7. Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. Shimizu T, Takahata M, Kameda Y, Hamano H, Ito T, Kimura-Suda H, Todoh M, Tadano S, Iwasaki N. Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. Bone. 2014 Jul;64:95-101. doi: 10.1016/j.bone.2014.04.005. Epub 2014 Apr 13. PMID: 24731926.

https://pubmed.ncbi.nlm.nih.gov/24731926/

8. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. Ito A, Shirakawa H, Takumi N, Minegishi Y, Ohashi A, Howlader ZH, Ohsaki Y, Sato T, Goto T, Komai M. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. Lipids Health Dis. 2011 Sep 13;10:158. doi: 10.1186/1476-511X-10-158. PMID: 21914161; PMCID: PMC3180407.

https://pubmed.ncbi.nlm.nih.gov/21914161

9. Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis.

Takumi N, Shirakawa H, Ohsaki Y, Ito A, Watanabe T, Giriwono PE, Sato T, Komai M. Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis. Food Funct. 2011 Jul;2(7):406-11. doi: 10.1039/c1fo10058k. Epub 2011 Jun 13. PMID: 21894328.

https://pubmed.ncbi.nlm.nih.gov/21894328

10. Vitamin K and rheumatoid arthritis. Okamoto H. Vitamin K and rheumatoid arthritis. IUBMB Life. 2008 Jun;60(6):355-61. doi: 10.1002/iub.41. PMID: 18484089.

https://pubmed.ncbi.nlm.nih.gov/18484089

11. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture

Hodges SJ, Akesson K, Vergnaud P, Obrant K, Delmas PD. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J Bone Miner Res. 1993 Oct;8(10):1241-5. doi: 10.1002/jbmr.5650081012. PMID: 8256661.

https://pubmed.ncbi.nlm.nih.gov/8256661

12. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits.

Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, Mizuno S, Takahashi S, Tajima T, Nakamura T. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997 Oct;75(2):135-43. doi: 10.1254/jjp.75.135. PMID: 9414028.

https://pubmed.ncbi.nlm.nih.gov/9414028

13. The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification. Mandatori D, Pelusi L, Schiavone V, Pipino C, Di Pietro N, Pandolfi A. The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification. Nutrients. 2021 Apr 7;13(4):1222. doi: 10.3390/nu13041222. PMID: 33917175; PMCID: PMC8067793.

https://pubmed.ncbi.nlm.nih.gov/33917175

14. Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study.

Fusaro M, Noale M, Viola V, Galli F, Tripepi G, Vajente N, Plebani M, Zaninotto M, Guglielmi G, Miotto D, Dalle Carbonare L, D'Angelo A, Naso A, Grimaldi C, Miozzo D, Giannini S, Gallieni M; VItamin K Italian (VIKI) Dialysis Study Investigators. Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study. J Bone Miner Res. 2012 Nov;27(11):2271-8. doi: 10.1002/jbmr.1677. PMID: 22692665.

https://pubmed.ncbi.nlm.nih.gov/22692665/

15. Role of vitamin K and vitamin K-dependent proteins in vascular calcification Schurgers LJ, Dissel PE, Spronk HM, Soute BA, Dhore CR, Cleutjens JP, Vermeer C. Role of vitamin K and vitamin K-dependent proteins in vascular calcification. Z Kardiol. 2001;90 Suppl 3:57-63. doi: 10.1007/s003920170043. PMID: 11374034.

https://pubmed.ncbi.nlm.nih.gov/11374034

16. Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review) Wen L, Chen J, Duan L, Li S. Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review). Mol Med Rep. 2018 Jul;18(1):3-15. doi: 10.3892/mmr.2018.8940. Epub 2018 Apr 27. PMID: 29749440; PMCID: PMC6059683.

https://pubmed.ncbi.nlm.nih.gov/29749440

17. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification

Wallin R, Schurgers L, Wajih N. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. Thromb Res. 2008;122(3):411-7. doi: 10.1016/j.thromres.2007.12.005. Epub 2008 Jan 30. PMID: 18234293; PMCID: PMC2529147.

https://pubmed.ncbi.nlm.nih.gov/18234293

18. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats Spronk HM, Soute BA, Schurgers LJ, Thijssen HH, De Mey JG, Vermeer C. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. J Vasc Res. 2003 Nov-Dec;40(6):531-7. doi: 10.1159/000075344. Epub 2003 Dec 3. PMID: 14654717.

https://pubmed.ncbi.nlm.nih.gov/14654717

19. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits

Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, Mizuno S, Takahashi S, Tajima T, Nakamura T. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997 Oct;75(2):135-43. doi: 10.1254/jjp.75.135. PMID: 9414028.

https://pubmed.ncbi.nlm.nih.gov/9414028

20. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains Ronden JE, Groenen-van Dooren MM, Hornstra G, Vermeer C. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. Atherosclerosis. 1997 Jul 11;132(1):61-7. doi: 10.1016/s0021-9150(97)00087-7. PMID: 9247360.

https://pubmed.ncbi.nlm.nih.gov/9247360

21. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant? Lal, N., Berenjian, A. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant?. Appl Microbiol Biotechnol 104, 2765–2776 (2020).

https://link.springer.com/article/10.1007/s00253-020-10409-1

22. The role of vitamin K in soft-tissue calcification Theuwissen E, Smit E, Vermeer C. The role of vitamin K in soft-tissue calcification. Adv Nutr. 2012 Mar 1;3(2):166-73. doi: 10.3945/an.111.001628. PMID: 22516724; PMCID: PMC3648717.

https://pubmed.ncbi.nlm.nih.gov/22516724

23. Vitamin K2 and its Impact on Tooth Epigenetics Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen Submitted: December 28th 2015. Reviewed: December 5th 2016 Published: March 22nd 2017 https://www.intechopen.com/books/vitamin-k2-vital-for-health-and-wellbeing/vitamin-k2-and-its-impact-on-tooth-epigenetics

4.9
Rated 4.9 out of 5 stars
Based on 15 reviews
Total 5 star reviews: 14 Total 4 star reviews: 1 Total 3 star reviews: 0 Total 2 star reviews: 0 Total 1 star reviews: 0
100%would recommend this product
15 reviews
  • O
    Olivia
    Verified Buyer
    I recommend this product
    How old are you? 25-34
    What is your gender? Female
    Rated 5 out of 5 stars
    3 months ago
    Eliminated my tooth sensitivity

    I’ve had very sensitive teeth since giving birth to my second child in 2021. When I started taking this supplement regularly I noticed my sensitivity decreased. I ran out for a while when it was out of stock and my tooth sensitivity came back. Within a week of taking it again, it was gone.

  • CC
    Colleen C.
    Verified Buyer
    I recommend this product
    How old are you? Over 65
    What is your gender? Female
    Rated 5 out of 5 stars
    4 months ago
    Review of Regulate March 2024

    I have been on it for a week so I am feeling ok but not on long enough to know any big differences.

    I am having blood work done in a couple of weeks, so I will stay on it until then. My Vit D levels were 45 last blood work and I am hoping this will help me to bring those levels up to 70+ and into the normal range.

    I have a DNA SNP on Vit D Taq and therefore have always had very low Vit D levels. Only once i was normal after a 2 week vacation in Hawaii where i was in the sun all day. I was up to 79 after that but it didn't last long. That is the highest Vit D level that i am aware of in the the past 20 years. i am also using UVB blue room and getting a bit of color from it, so am hoping my levels of Vit D are being enhanced with both of these remedies. Thank you for a wonderful product with no additives. I am chemical sensitive also and grateful to buy PURE product. Cheers, Colleen

  • LC
    Lia C.
    Verified Buyer
    I recommend this product
    How old are you? 25-34
    What is your gender? Female
    Rated 5 out of 5 stars
    4 months ago
    Great Product

    Love that the taste is minimal, even my toddler accepts it! I haven’t seen yet such concentrated Vit K ! Will be buying again!

  • TM
    Tracy M.
    Verified Buyer
    I recommend this product
    How old are you? 55-64
    What is your gender? Female
    Rated 4 out of 5 stars
    4 months ago
    Haven’t been taking it to long

    I don’t take this on a daily basis. Have not been taking it long enough to say if it is helping or not.

  • TA
    Taylor A.
    Verified Buyer
    I recommend this product
    How old are you? 25-34
    What is your gender? Male
    Rated 5 out of 5 stars
    5 months ago
    👍👍

    Just like all of the other Lifeblud supplements… do your market research and try to find a better deal than them! Quantity and quality.

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