Anti-Inflammatory
Metabolism
Sleep

Glycine

$20.00 USD

The Pro-Metabolic Amino Acid

Description

Glycine delivers 99%+ pure glycine in a bovine gelatin capsule with no fillers or additives. Supports sleep quality, recovery, collagen production, stress resilience, and healthy metabolic function.

Quantity / Bottle

1 Bottle90 day supply$20.00 USD
Save 5%2 Pack180 day supply$38.00 USD
Save 10%3 Pack270 day supply$54.00 USD

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Increases insulin sensitivity*
Facilitates glutathione synthesis*
Protects against oxidative stress*
Blood glucose regulation*
Blood pressure regulation*
Improves sleep quality*
Increases bile production*
Liver protective*
Protein synthesis and wound healing*
Inhibits lipolysis (improving glucose metabolism)*
Anti-arthritis & anti-fibrotic*

*These Statements have not been evaluated by the Food and Drug Association, or Health Canada. These products are not meant to diagnose, treat, cure, or prevent any diseases.

Each bottle contains: 90 capsules
Servings per container: 90

Each capsule contains: L-Glycine: 950mg

Other ingredients: gelatin (bovine)

Take 1 capsule per day, with or without food at any time of day.

1. Gelatin, Stress, and Longevity. Ray Peat.

2. Heresco-Levy U, Javitt DC, Ermilov M, Mordel C, Silipo G, Lichtenstein M. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry. 1999 Jan;56(1):29-36. doi: 10.1001/archpsyc.56.1.29. PMID: 9892253.

3. Wang W, Wu Z, Dai Z, Yang Y, Wang J, Wu G. Glycine metabolism in animals and humans: implications for nutrition and health. Amino Acids. 2013 Sep;45(3):463-77. doi: 10.1007/s00726-013-1493-1. Epub 2013 Apr 25. PMID: 23615880.

4. Alves A, Bassot A, Bulteau AL, Pirola L, Morio B. Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases. Nutrients. 2019 Jun 16;11(6):1356. doi: 10.3390/nu11061356. PMID: 31208147; PMCID: PMC6627940.

5. Díaz-Flores M, Cruz M, Duran-Reyes G, Munguia-Miranda C, Loza-Rodríguez H, Pulido-Casas E, Torres-Ramírez N, Gaja-Rodriguez O, Kumate J, Baiza-Gutman LA, Hernández-Saavedra D. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure. Can J Physiol Pharmacol. 2013 Oct;91(10):855-60. doi: 10.1139/cjpp-2012-0341. Epub 2013 Jun 17. PMID: 24144057.

6. Zhong Z, Wheeler MD, Li X, Froh M, Schemmer P, Yin M, Bunzendaul H, Bradford B, Lemasters JJ. L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutr Metab Care. 2003 Mar;6(2):229-40. doi: 10.1097/00075197-200303000-00013. PMID: 12589194.

7. Miller RA, Harrison DE, Astle CM, Bogue MA, Brind J, Fernandez E, Flurkey K, Javors M, Ladiges W, Leeuwenburgh C, Macchiarini F, Nelson J, Ryazanov AG, Snyder J, Stearns TM, Vaughan DE, Strong R. Glycine supplementation extends lifespan of male and female mice. Aging Cell. 2019 Jun;18(3):e12953. doi: 10.1111/acel.12953. Epub 2019 Mar 27. PMID: 30916479; PMCID: PMC6516426.

8. Gannon MC, Nuttall JA, Nuttall FQ. The metabolic response to ingested glycine. Am J Clin Nutr. 2002 Dec;76(6):1302-7. doi: 10.1093/ajcn/76.6.1302. PMID: 12450897.

9. Bannai M, Kawai N. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep. J Pharmacol Sci. 2012;118(2):145-8. doi: 10.1254/jphs.11r04fm. Epub 2012 Jan 27. PMID: 22293292.

10. Sheth H, Hafez T, Glantzounis GK, Seifalian AM, Fuller B, Davidson BR. Glycine maintains mitochondrial activity and bile composition following warm liver ischemia-reperfusion injury. J Gastroenterol Hepatol. 2011 Jan;26(1):194-200. doi: 10.1111/j.1440-1746.2010.06323.x. PMID: 21175814.

11. Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes

12. Imenshahidi, M., Hossenzadeh, H. Effects of glycine on metabolic syndrome components: a review. J Endocrinol Invest 45, 927–939 (2022). https://doi.org/10.1007/s40618-021-01720-3

13. El-Hafidi M, Franco M, Ramírez AR, Sosa JS, Flores JAP, Acosta OL, Salgado MC, Cardoso-Saldaña G. Glycine Increases Insulin Sensitivity and Glutathione Biosynthesis and Protects against Oxidative Stress in a Model of Sucrose-Induced Insulin Resistance. Oxid Med Cell Longev. 2018 Feb 21;2018:2101562. doi: 10.1155/2018/2101562. PMID: 29675131; PMCID: PMC5841105.

14. Soh, J., Raventhiran, S., Lee, J.H. et al. The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review. GeroScience 46, 219–239 (2024). https://doi.org/10.1007/s11357-023-00970-8

Glycine

Main Benefits

The anti-stress amino acid modern diets forgot.

Better sleep

Lowers core body temperature before sleep and calms neural activity for deeper, more restorative rest.

Less stress & anxiety

Acts as an inhibitory neurotransmitter — one of the nervous system's primary brakes on stress and overactivation.

Better metabolism

Improves insulin sensitivity, supports glutathione synthesis, and counters the anti-metabolic effects of excess methionine and tryptophan.

Cellular protection

Protects mitochondria from free radical damage, inflammation, and calcium overload at the cellular level.

The Problem

Modern diets are quietly creating a glycine crisis.

We eat almost exclusively muscle meat — chicken breasts, steaks, protein shakes — and discard the collagen-rich cuts that once supplied glycine naturally. The result is a severe amino acid imbalance that shows up in metabolic disorders, poor sleep, chronic inflammation, and impaired recovery.

Glycine addresses this directly — restoring the anti-stress amino acid that nose-to-tail eating once provided, and rebalancing the amino acid profile that modern diets have disrupted.

✓Inhibits inflammatory cell activation

✓Precursor to glutathione & collagen

✓Stimulates GABA production

✓Restores insulin sensitivity

The Science

Why your body needs Glycine.

01 · The Backstory

Modern diets have quietly created a glycine crisis.

Around 50% of all protein in an animal is collagen — and roughly 35% of collagen's amino acids are glycine. Traditional nose-to-tail eating supplied this naturally. Today, most people eat almost exclusively muscle meat: chicken breasts, steaks, protein shakes.

Over time, this creates a severe amino acid imbalance — glycine deficiency alongside excess cysteine, tryptophan, and methionine, all of which become anti-metabolic and inflammatory without glycine to balance them. Serum glycine deficiency is consistently observed in metabolic disorders including diabetes, obesity, hypertension, and fatty liver.

02 · The Anti-Stress Amino Acid

Glycine quiets the body at the cellular level.

Glycine is an inhibitory neurotransmitter — one of the brain and nervous system's primary brakes. It supports natural sleep, promotes recovery from neurological stress, and improves learning and memory.

But its quieting effect goes deeper than the brain. In every cell type, glycine appears to exert the same protective, antistress action — preventing fibrosis, free radical damage, inflammation, ATP depletion, calcium overload, and mitochondrial damage. It also directly counteracts the downstream harm caused by excess tryptophan and serotonin.

03 · Sleep & Metabolism

Glycine improves sleep quality and insulin sensitivity.

Glycine lowers core body temperature before sleep — one of the body's primary signals to initiate deep rest — and has been shown in both animal and human studies to measurably improve sleep quality and next-day cognitive function.

On the metabolic side, glycine increases insulin sensitivity, supports glutathione synthesis, regulates blood glucose, and reduces oxidative stress. Deficiency in this single amino acid can quietly impair multiple metabolic processes simultaneously.

04 · Longevity & Liver Health

Glycine extends lifespan and supports the liver.

Glycine is used by the body to produce glutathione, creatine, collagen, heme, bile, and nucleic acids — a list that spans virtually every major biological repair system. In the liver, it conjugates with bile acids to form bile salts alongside taurine, supporting fat digestion and fat-soluble vitamin absorption.

A 2019 study found that glycine supplementation extended the lifespan of both male and female mice — one of the few single nutrients ever to demonstrate this effect in controlled conditions.

Our Glycine

99%+ pure L-Glycine — no fillers or additives
High purity, lab-validated ingredients
Bovine gelatin capsules for easy digestion
3rd-party tested for bacteria, mold, and heavy metals

Other Glycine

Lower purity grades with undisclosed fillers
No third-party contaminant testing
Synthetic or plant-based capsules — harder to digest
Marketed narrowly as a sleep aid — missing the full picture

Add To Cart

› Why are so many people deficient in glycine?

Modern diets focus almost entirely on muscle meat (chicken breast, steak) while discarding the collagen-rich cuts traditionally eaten. About 35% of amino acids in gelatin/collagen are glycine — cutting out those foods creates a significant glycine deficit over time.

› What is the problem with eating too much muscle meat without glycine?

Muscle meat is high in methionine, cysteine, and tryptophan. Without the balancing effect of glycine, these amino acids can become anti-metabolic — promoting inflammation, estrogen-like effects, and suppressing metabolic rate.

› How does glycine improve sleep?

Glycine acts as an inhibitory neurotransmitter in the central nervous system — calming neurological activity and lowering core body temperature, both of which are associated with deeper, more restorative sleep.

› What does glycine produce in the body?

Glycine is a precursor to glutathione (master antioxidant), creatine (energy), collagen (structural protein), heme (oxygen transport), bile acids, and nucleic acids (DNA/RNA).