B Vitamin Complex

Energi+

Name: Energi+
Brand: LifeBlud
Price: 36.0 USD
Availability: InStock
Rating: 4.8 (93 reviews)

$36.00 USD

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93 reviews

The Best B Complex on Earth

Energi+ is formulated with the best and most bioactive forms of the B Vitamins in amounts that coincide with the bioenergetic perspective of optimizing cellular energy production. Using the right forms of the Bs is crucial for proper methylation and overall metabolic effectiveness.

The following are the major upgrades you get with Energi+, as opposed to other B-Complex products out there.

Benfotiamine instead of Thiamine HCl
Niacinamide instead of Niacin
L-5-methyl folate instead of Folic Acid
Adenosylcobalamin instead of Methylcobalamin
Pantethine instead of Pantothenic Acid
Bovine gelatin capsule instead of cellulose capsule

Check out the supplement background tab for a B Vitamin Crash Course.

Third-party lab tested for purity.

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Supplement Facts

Each bottle contains: 120 capsules
Servings per bottle: 60

Each capsule contains:
B1: Benfotiamine : 50mg
B2: Riboflavin 5-Phosphate: 25mg
B3: Niacinamide : 125mg
B5: Pantethine: 10mg
B6: Pyridoxal-5-Phosphate : 5mg
B9: L-5-MTHF: 500mcg
B12: Adenosylcobalamin: 500mcg
Biotin: 25mcg
Inositol: 25mg

Non medicinal ingredients: NuRice, gelatin capsule (bovine), NuMag.

*NuRice and NuMag are rice hull products that help us blend the many ingredients of Energi+ together evenly, so each capsule can be filled evenly.

Benefits

B1 Thiamine

Plays a critical role in the metabolism of carbohydrates into energy*
Cofactor for the enzyme Pyruvate Dehydrogenase (PDH)*
PDH is one of the main enzymes that converts glucose from carbohydrate into energy*
Used in synthesis of the neurotransmitter acetylcholine (ACH)*
Improve glucose use*

B2 Riboflavin

Required for FAD and FMN which are mitochondrial energy production enzymes*
Assists in carbohydrate, fat, and protein metabolism*
Facilitates the normalization of MTHFR enzyme activity*
Assists glutathione recycling*

B3 Niacinamide

Stimulates mitochondrial energy production*
Lowers free fatty acids in the blood*
Assists greatly with carbohydrate metabolism*
Increase NAD+*
May lower cholesterol*
Neuroprotection*

B5 Pantothenic Acid

Energy metabolism*
Synthesis of coenzyme A (Acetyl-CoA - mitochondrial energy molecule!)*
Supports myelin production & neurotransmitter Acetylcholine*

B6 Pyridoxine

Helps recycle cysteine into glutathione*
Required in monoamine synthesis (dopamine, GABA, serotonin, epinephrines)*
Energy metabolism*
Aids liver detoxification*

B7 Biotin

Involved in hair, skin, and nail health*
Coenzyme in carboxylation reactions*
Aids insulin production*
Aids aerobic oxidative metabolism*

B9 Folate

DNA synthesis & repair*
Methylation*
Amino acid metabolism & conversion*
Homocysteine regulation*
Blood cell production*
Required in rapid cell division & growth*
Can help prevent neural tube defects*
Methylfolate prevents glycine wasting*

B12 Cobalamin

New red blood cell production*
Used alongside B9 in homocysteine regulation*
DNA synthesis & repair*
Aids in energy metabolism*
Helps maintain nerve sheaths*

Inositol

Improves insulin sensitivity*
Aids liver function *
Hormone balance*
Mood improvement*

*These Statements have not been evaluated by the Food and Drug Association, or Health Canada. These products are not meant to diagnose, treat, cure, or prevent any diseases.

How to Take

Take 2 capsules daily, at two separate times throughout the day. With food is recommended but not strictly necessary.

The capsules may be opened up and mixed into a beverage to consume gradually through the day.

B Vitamins play a crucial role in numerous physiological functions, but their significance in energy metabolism is unparalleled.

When we consume carbohydrates, proteins, or fats, the body must convert these dietary inputs into acetyl-CoA, which kicks off the energy production process in the mitochondria.

In the mitochondria, The Citric Acid Cycle (TCA) (a.k.a Kreb's Cycle) and the Electron Transport Chain (ETC) are responsible for the majority of our energy (ATP) production.

The important thing to note here is that these energy processes involve many steps, and each step is facilitated by an enzyme. Enzymes require micronutrients for their function, such as Magnesium, Copper, Zinc, Vitamin C, and, of course, the B vitamins.

Ingredient Spotlights:

Benfotiamine

Benfotiamine is a fat-soluble form of Vitamin B1 Thiamine. It has been extensively studied to have a much higher bioavailable capacity than the standard Thiamine HCl. Since it is fat-soluble and not water-soluble, it can stay in the system for a longer period of time without being excreted. Research suggests it is 3-4x as effective [2,3].

Benfotiamine not only delivers a more bioactive array of benefits from Vitamin B1 around improving glucose utilization, pyruvate dehydrogenase activation, anti-tumour and anti-cancer effects, and neuroprotection [4-7] but also has added benefits of antioxidant and anti-inflammatory effect. It has been shown to reduce DNA damage [8] and mediate the inflammatory response caused by endotoxin (LPS) and PUFA [9].

Alcohol and Vitamin B1 have an inverse relationship, and there is evidence to suggest that B1 deficiency caused by alcohol consumption can cause iron-mediated brain damage [12]. B1 seems to be a very crucial component when it comes to recovering from alcohol use. Benfotiamine has also been shown to have a liver protective effect [11].

Niacinamide

Niacinamide does not need much of an introduction at this point. However, it is important to note that Niacinamide is much preferred over Niacin, as it commonly induces a 'flushing' reaction, which is just a nice way of saying inflammatory response [14].

Not only does Niacinamide not induce this inflammatory response, but it dramatically increases our ability to utilize carbohydrates as energy, lowers free fatty acids in the blood, and increases cellular NAD+ levels. These processes make it an incredible tool, especially for someone who needs help switching to a diet with an emphasis on burning carbohydrates efficiently as fuel.

Important to note, though, is that increased Niacinamide intake also requires an increased demand for methyl donors [15]. Niacinamide must be methylated and, therefore, can use high amounts of methyl donors. These donors are choline, methionine, B9 Folate, and B12. Energi+ contains the most biologically active forms of both B9 and B12 to compensate for this.

L5-Methyl Folate (MTHF)

L-5-MTHF is the most biologically active form of folate found in nature and whole foods. Most supplemental folates are in the form of Folic Acid. The body has to convert folic acid into methylfolate, and many people struggle with that process due to stress, current biological situation, genetics, and so forth. Unmetabolized folic acid in the body can cause problems [16-17].

L-5-MTHF can support methylation in tandem with B12, which will maximize the efficiency of supplemental Niacinamide and help many other processes, such as DNA synthesis, hormone conversion, and homocysteine regulation.

Adenosylcobalamin

Adenosylcobalamin is the form of B12 used directly in the mitochondria to create energy in the Citric Acid Cycle.

Most B complexes contain Methylcobalamin. Similar to L-5-MTHF, the body must convert Methylcobalamin into Adenosylcobalamin for it to be used to create energy in the cell [18-19]. This makes Adenosylcobalamin the best choice for taking a B12 supplement that will be easily absorbed by the body and assist in the energy production process as best possible.

*These Statements have not been evaluated by the Food and Drug Association, or Health Canada. These products are not meant to diagnose, treat, cure, or prevent any diseases.

1. Institute of Medicine. 1998. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press. https://doi.org/10.17226/6015. https://www.nap.edu/read/6015/chapter/1

2. Xie F, Cheng Z, Li S, Liu X, Guo X, Yu P, Gu Z. Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride. J Clin Pharmacol. 2014 Jun;54(6):688-95. doi: 10.1002/jcph.261. Epub 2014 Jan 22. PMID: 24399744. https://pubmed.ncbi.nlm.nih.gov/24399744/

3. Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. Int J Clin Pharmacol Ther. 1996 Feb;34(2):47-50. PMID: 8929745. https://pubmed.ncbi.nlm.nih.gov/8929745/

4. Lee BY, Yanamandra K, Bocchini JA Jr. Thiamin deficiency: a possible major cause of some tumors? (review). Oncol Rep. 2005 Dec;14(6):1589-92. PMID: 16273261. https://pubmed.ncbi.nlm.nih.gov/16273261/

5. siteleĭ [Thiamine and pyruvate Velichko MG, Ostrovskiĭ IuM, Trebukhina RV. Tiamin i obmen piruvata u krys-opukholenometabolism in tumor-bearing rats]. Vopr Med Khim. 1978 Mar-Apr;24(2):220-4. Russian. PMID: 664448. https://pubmed.ncbi.nlm.nih.gov/664448/

6. Sambon M, Wins P, Bettendorff L. Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine. Int J Mol Sci. 2021 May 21;22(11):5418. doi: 10.3390/ijms22115418. PMID: 34063830; PMCID: PMC8196556. https://pubmed.ncbi.nlm.nih.gov/34063830/

7. Hanberry, B.S., Berger, R. & Zastre, J.A. High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate. Cancer Chemother Pharmacol 73, 585–594 (2014). https://doi.org/10.1007/s00280-014-2386-z

8. Schmid U, Stopper H, Heidland A, Schupp N. Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro. Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):371-7. doi: 10.1002/dmrr.860. PMID: 18384109. https://pubmed.ncbi.nlm.nih.gov/18384109/

9. Shoeb M, Ramana KV. Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med. 2012;52(1):182-190. doi:10.1016/j.freeradbiomed.2011.10.444 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249497/

10. Fraser, D.A., Hessvik, N.P., Nikolić, N. et al. Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations. Genes Nutr 7, 459–469 (2012). https://doi.org/10.1007/s12263-011-0252-8 https://genesandnutrition.biomedcentral.com/articles/10.1007/s12263-011-0252-8

11. Aziz, T. Effect of benfotiamine on hepatic tissue levels of free calcium, copper, iron and zinc during CCl4-induced hepatotoxicity in rats. Zanco J. Med. Sci., Vol. 15, No. (2), 2011. https://www.researchgate.net

12. Medical University of Vienna. "Vitamin B1 deficiency a key factor in the development of alcohol-related dementia: Hypothesis describes the role of iron deposits in the brain as the cause of dementia in alcoholics." ScienceDaily. ScienceDaily, 9 September 2020. https://www.sciencedaily.com/releases/2020/09/200909100248.htm

13. Balakumar P, Rohilla A, Krishan P, Solairaj P, Thangathirupathi A. The multifaceted therapeutic potential of benfotiamine. Pharmacol Res. 2010 Jun;61(6):482-8. doi: 10.1016/j.phrs.2010.02.008. Epub 2010 Feb 25. PMID: 20188835. https://pubmed.ncbi.nlm.nih.gov/20188835/

14. Kamanna VS, Ganji SH, Kashyap ML. The mechanism and mitigation of niacin-induced flushing. Int J Clin Pract. 2009 Sep;63(9):1369-77. doi: 10.1111/j.1742-1241.2009.02099.x. PMID: 19691622; PMCID: PMC2779993. https://pubmed.ncbi.nlm.nih.gov/19691622/

15. Sun WP, Li D, Lun YZ, Gong XJ, Sun SX, Guo M, Jing LX, Zhang LB, Xiao FC, Zhou SS. Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives. Hypertens Res. 2012 Feb;35(2):180-5. doi: 10.1038/hr.2011.151. Epub 2011 Sep 15. PMID: 21918528. https://pubmed.ncbi.nlm.nih.gov/21918528/

16. Henderson AM, Aleliunas RE, Loh SP, Khor GL, Harvey-Leeson S, Glier MB, Kitts DD, Green TJ, Devlin AM. l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women. J Nutr. 2018 Jun 1;148(6):885-890. doi: 10.1093/jn/nxy057. PMID: 29878267. https://pubmed.ncbi.nlm.nih.gov/29878267/

17. Seremak-Mrozikiewicz A. Metafolina--alternatywa dla suplementacji niedoboru folianów u kobiet ciezarnych [Metafolin--alternative for folate deficiency supplementation in pregnant women]. Ginekol Pol. 2013 Jul;84(7):641-6. Polish. doi: 10.17772/gp/1618. PMID: 24032278. https://pubmed.ncbi.nlm.nih.gov/24032278/

18. Thakkar K, Billa G. Treatment of vitamin B12 deficiency-methylcobalamine? Cyancobalamine? Hydroxocobalamin?-clearing the confusion. Eur J Clin Nutr. 2015 Jan;69(1):1-2. doi: 10.1038/ejcn.2014.165. Epub 2014 Aug 13. PMID: 25117994. https://pubmed.ncbi.nlm.nih.gov/25117994/

19. Marsh EN, Meléndez GD. Adenosylcobalamin enzymes: theory and experiment begin to converge. Biochim Biophys Acta. 2012 Nov;1824(11):1154-64. doi: 10.1016/j.bbapap.2012.03.012. Epub 2012 Apr 3. PMID: 22516318; PMCID: PMC3580769. https://pubmed.ncbi.nlm.nih.gov/22516318/

4.8

Rated 4.8 out of 5 stars

Based on 93 reviews

Total 5 star reviews: 86 Total 4 star reviews: 1 Total 3 star reviews: 2 Total 2 star reviews: 0 Total 1 star reviews: 4

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KC
Kunal C.
Verified Buyer
Reviewing
Energi+
I recommend this product
Rated 5 out of 5 stars
3 months ago
The best
More than your average B complex.
The best on the market. Bio-available Methylated forms. Clinically effective doses.
I’ve taken in consistently for over 2 years. I don’t travel without it and recommend it to everyone I know.
Was this helpful?
AL
Allyssa L.
Verified Buyer
Reviewing
Energi+
I recommend this product
How old are you? 25-34
What is your gender? Female
Rated 5 out of 5 stars
1 year ago
So good!
I've been taking Energi+ for months! Love it, the best I've ever come across and recommended by many.
Love all LifeBlud products 🙌
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VW
Vanessa W.
Verified Buyer
Reviewing
Energi+
I recommend this product
Rated 5 out of 5 stars
24 minutes ago
Great product!
The perfect amount!
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DA
Daniel A.
Verified Buyer
Reviewing
Energi+
I recommend this product
Rated 5 out of 5 stars
2 days ago
Amazing product
I’ve been using LifeBlud’s Energi daily for several years. Hands down best b complex on the market. I use several other LifeBlud products, too, all of which are exceptional.
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SH
Susan H.
Verified Buyer
Reviewing
Energi+
I recommend this product
Rated 5 out of 5 stars
3 weeks ago
Love this
I have much more energy and clear thoughts. Imo they help with brain fog
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