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L-Glycine

Glycine

$25.00 USD
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Glycine Capsules

L-Glycine (99+% purity) in a bovine gelatin capsule. Nothing else. 

The Pro-Metabolic Amino Acid.

Third-party lab tested for purity.

Supplement Facts

​​Each bottle contains: 90 capsules
Servings per container: 90

Each capsule contains: L-Glycine: 950mg

Other ingredients: gelatin (bovine)

Benefits

  • Increases insulin sensitivity*
  • Facilitates glutathione synthesis*
  • Protects against oxidative stress*
  • Blood glucose regulation*
  • Blood pressure regulation*
  • Improves sleep quality*
  • Increases bile production*
  • Liver protective*
  • Protein synthesis and wound healing*
  • Inhibits lipolysis (improving glucose metabolism)*
  • Anti-arthritis & anti-fibrotic*

*These Statements have not been evaluated by the Food and Drug Association, or Health Canada. These products are not meant to diagnose, treat, cure, or prevent any diseases.

How to Take

Take 1 capsule per day, with or without food at any time of day.

Glycine: The Pro-Metabolic Amino Acid

The following is a quote from Ray Peat's article titled "Gelatin, stress, and longevity"

"A generous supply of glycine/gelatin, against a balanced background of amino acids, has a great variety of antistress actions. Glycine is recognized as an “inhibitory” neurotransmitter, and promotes natural sleep. Used as a supplement, it has helped to promote recovery from strokes and seizures, and to improve learning and memory. But in every type of cell, it apparently has the same kind of quieting, protective antistress action. The range of injuries produced by an excess of tryptophan and serotonin seems to be prevented or corrected by a generous supply of glycine. Fibrosis, free radical damage, inflammation, cell death from ATP depletion or calcium overload, mitochondrial damage, diabetes, etc., can be prevented or alleviated by glycine." 

Glycine is used in the body to produce glutathione, heme, creatine, collagen, bile, and nucleic acids. It is considered a 'non-essential' amino acid by some, and a 'conditionally essential' amino acid by others, but there is sufficient evidence to support that the amount of glycine we synthesize within our bodies is not enough to meet the demands of our daily stressors.

Glycine, like taurine, is a component of bile acids, which are crucial to our digestion of fat and assimilation of fat-soluble vitamins. This makes it a very important amino acid for liver health and detoxification.

Glycine supplementation is observed to have many benefits on the metabolic, nervous, and endocrine systems. Improving insulin sensitivity, reducing blood glucose, inhibiting excitatory neurotransmitters, improving sleep quality, promoting wound healing and cognition are of the many known benefits of glycine supplementation. 

Conversely, a deficiency of serum glycine can be observed in many cases of metabolic disorders such as diabetes, obesity, hypertension, hyperlipidemia and fatty liver. 

It was Ray, maybe alongside Weston. A. Price, who really highlighted and popularized the notion of 'nose-to-tail' eating, and returning to a more traditional way of consuming the whole animal, as each part has its own nutritional characteristics and benefits, and without them we may fall out of balance. He mainly highlighted this because of the fact that around 50% of all protein in an animal is collagen, which is what becomes gelatin when cooked. Of that gelatin, about 35% of all amino acids within it are glycine.

Highly industrialized societies have gravitated away from the consumption of nose-to-tail collagenous meats, in favor of pure muscle meats such as chicken breasts and steaks as the main protein sources.

Eating this way over a lifetime, and as a majority of the diet will cause severe amino acid imbalance, with glycine deficiencies and excess of cysteine, tryptophan, and methionine which can become anti-metabolic and inflammatory. Glycine supplementation has shown to be incredibly valuable in this context. 

1. Gelatin, Stress, and Longevity. Ray Peat. 

2. Heresco-Levy U, Javitt DC, Ermilov M, Mordel C, Silipo G, Lichtenstein M. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry. 1999 Jan;56(1):29-36. doi: 10.1001/archpsyc.56.1.29. PMID: 9892253.

3. Wang W, Wu Z, Dai Z, Yang Y, Wang J, Wu G. Glycine metabolism in animals and humans: implications for nutrition and health. Amino Acids. 2013 Sep;45(3):463-77. doi: 10.1007/s00726-013-1493-1. Epub 2013 Apr 25. PMID: 23615880.

4. Alves A, Bassot A, Bulteau AL, Pirola L, Morio B. Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases. Nutrients. 2019 Jun 16;11(6):1356. doi: 10.3390/nu11061356. PMID: 31208147; PMCID: PMC6627940.

5. Díaz-Flores M, Cruz M, Duran-Reyes G, Munguia-Miranda C, Loza-Rodríguez H, Pulido-Casas E, Torres-Ramírez N, Gaja-Rodriguez O, Kumate J, Baiza-Gutman LA, Hernández-Saavedra D. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure. Can J Physiol Pharmacol. 2013 Oct;91(10):855-60. doi: 10.1139/cjpp-2012-0341. Epub 2013 Jun 17. PMID: 24144057.

6. Zhong Z, Wheeler MD, Li X, Froh M, Schemmer P, Yin M, Bunzendaul H, Bradford B, Lemasters JJ. L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutr Metab Care. 2003 Mar;6(2):229-40. doi: 10.1097/00075197-200303000-00013. PMID: 12589194.

7. Miller RA, Harrison DE, Astle CM, Bogue MA, Brind J, Fernandez E, Flurkey K, Javors M, Ladiges W, Leeuwenburgh C, Macchiarini F, Nelson J, Ryazanov AG, Snyder J, Stearns TM, Vaughan DE, Strong R. Glycine supplementation extends lifespan of male and female mice. Aging Cell. 2019 Jun;18(3):e12953. doi: 10.1111/acel.12953. Epub 2019 Mar 27. PMID: 30916479; PMCID: PMC6516426. 

8. Gannon MC, Nuttall JA, Nuttall FQ. The metabolic response to ingested glycine. Am J Clin Nutr. 2002 Dec;76(6):1302-7. doi: 10.1093/ajcn/76.6.1302. PMID: 12450897.

9. Bannai M, Kawai N. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep. J Pharmacol Sci. 2012;118(2):145-8. doi: 10.1254/jphs.11r04fm. Epub 2012 Jan 27. PMID: 22293292.

10. Sheth H, Hafez T, Glantzounis GK, Seifalian AM, Fuller B, Davidson BR. Glycine maintains mitochondrial activity and bile composition following warm liver ischemia-reperfusion injury. J Gastroenterol Hepatol. 2011 Jan;26(1):194-200. doi: 10.1111/j.1440-1746.2010.06323.x. PMID: 21175814.

11. Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes

12. Imenshahidi, M., Hossenzadeh, H. Effects of glycine on metabolic syndrome components: a review. J Endocrinol Invest 45, 927–939 (2022). https://doi.org/10.1007/s40618-021-01720-3

13. El-Hafidi M, Franco M, Ramírez AR, Sosa JS, Flores JAP, Acosta OL, Salgado MC, Cardoso-Saldaña G. Glycine Increases Insulin Sensitivity and Glutathione Biosynthesis and Protects against Oxidative Stress in a Model of Sucrose-Induced Insulin Resistance. Oxid Med Cell Longev. 2018 Feb 21;2018:2101562. doi: 10.1155/2018/2101562. PMID: 29675131; PMCID: PMC5841105.

14. Soh, J., Raventhiran, S., Lee, J.H. et al. The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review. GeroScience 46, 219–239 (2024). https://doi.org/10.1007/s11357-023-00970-8