vitamin k2 mk7 fermented natto bone health calcium heart health

Vitamin K2

MK-Seven

Name: MK-Seven
Brand: LifeBlud
Price: 14.0 USD
Availability: InStock
Rating: 4.8 (25 reviews)

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25 reviews

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Vitamin K2 Mk7 capsules

From MenaQ7, a naturally fermented, highly pure, allergen free, all-trans isomer menaquinone-7. Clinically validated and rigorously tested to be the highest quality and most bioavailable K2 Mk7 on the market.

Supports calcium regulation for optimized dental, bone, and cardiovascular health.

Third-party lab tested for purity.

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Supplement Facts

Each bottle contains: 120 capsules
Servings per container: 120

Each capsule contains: Vitamin K2 Mk7 (MenaQ7®) 120 mcg

Other ingredients: NuRice, gelatin capsule (bovine), microcrystalline cellulose, mct oil.

Benefits

Bone health* [3-7,11]
Cardiovascular function* [12-16]
Calcium regulation and homeostasis*
Dental health* [23]
Blood pressure regulation*
Helps prevent osteo- conditions* [1-2,6]
Facilitates cellular energy production*
Protects against soft tissue and arterial calcification* [17-20]
Improves testosterone production* [8-9]
Regulates nervous system & brain health*

*These Statements have not been evaluated by the Food and Drug Association, or Health Canada. These products are not meant to diagnose, treat, cure, or prevent any diseases.

How to Take

Take 1 capsule daily with food.

For an in-depth look at Vitamin K2 and a comparison of MK-Seven and Regulate, check out Vitamin K: A General Guide. Vitamin K2 is the ultimate calcium regulator. Calcium regulation is the hallmark of dental, bone, artery, and cell health. Of course, calcium is an incredibly important mineral in our body and thus should be in our diet as well. But it must be in the right place.

Blood calcium is the primary regulator of Parathyroid Hormone (PTH) secretion, which can be thrown off by consuming more phosphorus than calcium (See blog post: 'Meat in Context'). Otherwise, the vast majority of calcium we get should be in the bones.

High phosphorus intake, without adequate calcium intake, will raise PTH, causing calcium to be pulled out of the bones and into the blood. When this becomes chronic, it can result in osteoporosis and other osteo-related conditions.

Both magnesium and Vitamin K2 play the role of directing calcium to where it belongs.

When calcium is deposited into the soft tissues, the buildup results in soft tissue calcification, leading to stiff and aching muscles.

When calcium is deposited in the blood vessels and arteries, it leads to arterial plaque, which can cause serious cardiovascular issues and high blood pressure.

During stress, calcium floods into the cell, causing cellular inflammation, excitation, and even cell death.

Vitamin K2 is crucial in pulling calcium out of the soft tissues and the arteries and directing it back into the bone, preventing harmful buildup.

These above issues are some of the main culprits of aging.

1. Bunyaratavej N, Kittimanon N, Jitivirai T, Tongthongthip B. Highly recommended dose of MK4 for osteoporosis. J Med Assoc Thai. 2009 Sep;92 Suppl5:S4-6. PMID: 19894328.

2. Hart JP, Shearer MJ, Klenerman L, Catterall A, Reeve J, Sambrook PN, Dodds RA, Bitensky L, Chayen J. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. J Clin Endocrinol Metab. 1985 Jun;60(6):1268-9. doi: 10.1210/jcem-60-6-1268. PMID: 3998071.

3. Kaneki M, Hosoi T, Ouchi Y, Orimo H. Pleiotropic actions of vitamin K: protector of bone health and beyond? Nutrition. 2006 Jul-Aug;22(7-8):845-52. doi: 10.1016/j.nut.2006.05.003. PMID: 16815498.

4. Nakamura E, Aoki M, Watanabe F, Kamimura A. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. Nutr J. 2014 Aug 27;13:85. doi: 10.1186/1475-2891-13-85. PMID: 25163392

5. Inaba N, Sato T, Yamashita T. Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials. J Nutr Sci Vitaminol (Tokyo). 2015;61(6):471-80. doi: 10.3177/jnsv.61.471. PMID: 26875489.

6. Vitamin K₂ therapy for postmenopausal osteoporosis. Iwamoto J. Vitamin K₂ therapy for postmenopausal osteoporosis. Nutrients. 2014 May 16;6(5):1971-80. doi: 10.3390/nu6051971. PMID: 24841104; PMCID: PMC4042573.

7. Shimizu T, Takahata M, Kameda Y, Hamano H, Ito T, Kimura-Suda H, Todoh M, Tadano S, Iwasaki N. Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. Bone. 2014 Jul;64:95-101. doi: 10.1016/j.bone.2014.04.005. Epub 2014 Apr 13. PMID: 24731926.

8. Ito A, Shirakawa H, Takumi N, Minegishi Y, Ohashi A, Howlader ZH, Ohsaki Y, Sato T, Goto T, Komai M. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. Lipids Health Dis. 2011 Sep 13;10:158. doi: 10.1186/1476-511X-10-158. PMID: 21914161; PMCID: PMC3180407.

9. Takumi N, Shirakawa H, Ohsaki Y, Ito A, Watanabe T, Giriwono PE, Sato T, Komai M. Dietary vitamin K alleviates the reduction in testosterone production induced by lipopolysaccharide administration in rat testis. Food Funct. 2011 Jul;2(7):406-11. doi: 10.1039/c1fo10058k. Epub 2011 Jun 13. PMID: 21894328.

10. Okamoto H. Vitamin K and rheumatoid arthritis. IUBMB Life. 2008 Jun;60(6):355-61. doi: 10.1002/iub.41. PMID: 18484089.

11. Hodges SJ, Akesson K, Vergnaud P, Obrant K, Delmas PD. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J Bone Miner Res. 1993 Oct;8(10):1241-5. doi: 10.1002/jbmr.5650081012. PMID: 8256661.

12. Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, Mizuno S, Takahashi S, Tajima T, Nakamura T. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997 Oct;75(2):135-43. doi: 10.1254/jjp.75.135. PMID: 9414028.

13. Mandatori D, Pelusi L, Schiavone V, Pipino C, Di Pietro N, Pandolfi A. The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification. Nutrients. 2021 Apr 7;13(4):1222. doi: 10.3390/nu13041222. PMID: 33917175; PMCID: PMC8067793.

14. Fusaro M, Noale M, Viola V, Galli F, Tripepi G, Vajente N, Plebani M, Zaninotto M, Guglielmi G, Miotto D, Dalle Carbonare L, D'Angelo A, Naso A, Grimaldi C, Miozzo D, Giannini S, Gallieni M; Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study. J Bone Miner Res. 2012 Nov;27(11):2271-8. doi: 10.1002/jbmr.1677. PMID: 22692665.

15. Schurgers LJ, Dissel PE, Spronk HM, Soute BA, Dhore CR, Cleutjens JP, Vermeer C. Role of vitamin K and vitamin K-dependent proteins in vascular calcification. Z Kardiol. 2001;90 Suppl 3:57-63. doi: 10.1007/s003920170043. PMID: 11374034.

16. Wen L, Chen J, Duan L, Li S. Vitamin K‑dependent proteins involved in bone and cardiovascular health (Review). Mol Med Rep. 2018 Jul;18(1):3-15. doi: 10.3892/mmr.2018.8940. Epub 2018 Apr 27. PMID: 29749440; PMCID: PMC6059683.

17. Wallin R, Schurgers L, Wajih N. Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification. Thromb Res. 2008;122(3):411-7. doi: 10.1016/j.thromres.2007.12.005. Epub 2008 Jan 30. PMID: 18234293; PMCID: PMC2529147.

18. Spronk HM, Soute BA, Schurgers LJ, Thijssen HH, De Mey JG, Vermeer C. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. J Vasc Res. 2003 Nov-Dec;40(6):531-7. doi: 10.1159/000075344. Epub 2003 Dec 3. PMID: 14654717.

19. Kawashima H, Nakajima Y, Matubara Y, Nakanowatari J, Fukuta T, Mizuno S, Takahashi S, Tajima T, Nakamura T. Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits. Jpn J Pharmacol. 1997 Oct;75(2):135-43. doi: 10.1254/jjp.75.135. PMID: 9414028.

20. Ronden JE, Groenen-van Dooren MM, Hornstra G, Vermeer C. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. Atherosclerosis. 1997 Jul 11;132(1):61-7. doi: 10.1016/s0021-9150(97)00087-7. PMID: 9247360.

21. Lal, N., Berenjian, A. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant?. Appl Microbiol Biotechnol 104, 2765–2776 (2020).

22. Theuwissen E, Smit E, Vermeer C. The role of vitamin K in soft-tissue calcification. Adv Nutr. 2012 Mar 1;3(2):166-73. doi: 10.3945/an.111.001628. PMID: 22516724; PMCID: PMC3648717.

23. Vitamin K2 and its Impact on Tooth Epigenetics Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen Submitted: December 28th 2015. Reviewed: December 5th 2016 Published: March 22nd 2017

4.8

Rated 4.8 out of 5 stars

Based on 25 reviews

Total 5 star reviews: 22 Total 4 star reviews: 1 Total 3 star reviews: 2 Total 2 star reviews: 0 Total 1 star reviews: 0

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KC
Kunal C.
Verified Buyer
I recommend this product
How old are you? 25-34
What is your gender? Male
Rated 5 out of 5 stars
1 year ago
MK
I live an overall very healthy lifestyle, therefore I haven’t noticed any significant perceptible effects from taking MK-7 in particular. However, I have a lot of trust and faith in Lifeblud and the quality of these supplements and products. I also understand the importance and benefits of supplementing with a quality MK-7 product as our diets and modern environment require it and have left the majority of us majorly deficient. I would need to get blood work and scans done, to showcase demonstrative affect, but I am very happy with this and the rest of Lifeblud’s supplements. The affordability. Quality. Transparency. Sourcing. And integrity that has been put in and demonstrated by the company and Adam Marafioti has won my confidence and satisfaction.
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MN
Michelle N.
Verified Buyer
I recommend this product
Rated 5 out of 5 stars
13 seconds ago
Excellent product!
Great to have clean supplements from LifeBlud!
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VE
Virginia E.
Verified Buyer
I recommend this product
Rated 5 out of 5 stars
2 weeks ago
I trust the quality
I trust the quality of LifeBlud. Will most likely purchase again.
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LB
Laura B.
Verified Buyer
I recommend this product
Rated 5 out of 5 stars
1 month ago
Great supplement!
Great supplement! Helpful for bones.
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LH
Lyn H.
Verified Buyer
Rated 3 out of 5 stars
1 month ago
Too soon to tell
Product arrived quickly. But I haven’t been taking it long enough to notice differences
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